The placenta is essential for normal in utero development in mammals. In humans, defective
placental formation underpins common pregnancy disorders such as pre-eclampsia and …

Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and
mammalian target of rapamycin (mTOR) constitute the core components of the …

The human embryo undergoes morphogenetic transformations following implantation into
the uterus, but our knowledge of this crucial stage is limited by the inability to observe the …

Limited access to embryos has hampered the study of human embryogenesis and disorders
that occur during early pregnancy. Human pluripotent stem cells provide an alternative …

The ability to study human post-implantation development remains limited owing to ethical
and technical challenges associated with intrauterine development after implantation …

Investigating human development is a substantial scientific challenge due to the technical
and ethical limitations of working with embryonic samples. In the face of these difficulties …

Human pluripotent and trophoblast stem cells have been essential alternatives to
blastocysts for understanding early human development 1, 2, 3, 4. However, these simple …

Biomolecular and physical cues of the extracellular matrix environment regulate collective
cell dynamics and tissue patterning. Nonetheless, how the viscoelastic properties of the …

Abnormal placentation is considered as an underlying cause of various pregnancy
complications such as miscarriage, preeclampsia and intrauterine growth restriction, the …

Human naive pluripotent cells can differentiate into extraembryonic trophectoderm and
hypoblast. Here we describe a human embryo model (blastoid) generated by self …