Physical stimuli are essential for the function of eukaryotic cells, and changes in physical
signals are important elements in normal tissue development as well as in disease initiation …

Uncontrolled cell proliferation is the hallmark of cancer, and tumor cells have typically
acquired damage to genes that directly regulate their cell cycles. Genetic alterations …

Focal adhesions lie at the convergence of integrin adhesion, signaling and the actin
cytoskeleton. Cells modify focal adhesions in response to changes in the molecular …

Tight control of cell proliferation is required to ensure normal tissue patterning and prevent
cancer formation. The analysis of cultured cells has led to an explosion in our understanding …

Cell adhesion is critical for the genesis and maintenance of both three-dimensional structure
and normal function in tissues. The biochemical entities mediating cell adhesion are …

The extracellular matrix (ECM) plays an essential role in the regulation of cell proliferation
during angiogenesis. Cell adhesion to ECM is mediated by binding of cell surface integrin …

Integrins contribute to cell growth by providing a physical linkage between cytoskeletal
structures and the extracellular matrix, and also by participating in various signal …

The important contribution of aberrant Ras activation in oncogenesis is well established. Our
knowledge of the signaling pathways that are regulated by Ras is considerable. However …

The concept of anchorage-dependent growth and the close relationship between anchorage
independence and tumorigenicity were first appreciated more than a quarter century ago (9 …

An in vitro carcinogenesis model of human skin keratinocytes has been developed based on
the spontaneously immortalized keratinocyte cell line HaCaT. Immortalization, the initial …