The immunobiology of preterm labor and birth: intra-amniotic inflammation or breakdown of maternal–fetal homeostasis

N Gomez-Lopez, J Galaz, D Miller… - …, 2022 - rep.bioscientifica.com
In brief The syndrome of preterm labor comprises multiple established and novel etiologies.
This review summarizes the distinct immune mechanisms implicated in preterm labor and …

Periodontal disease and adverse pregnancy outcomes

YA Bobetsis, F Graziani, M Gürsoy… - Periodontology …, 2020 - Wiley Online Library
Periodontal diseases are considered not only to affect tooth‐supporting tissues but also to
have a cause‐and‐effect relationship with various systemic diseases and conditions, such …

[HTML][HTML] Evidence that intra-amniotic infections are often the result of an ascending invasion–a molecular microbiological study

R Romero, N Gomez-Lopez, AD Winters… - Journal of perinatal …, 2019 - degruyter.com
Background Microbial invasion of the amniotic cavity resulting in intra-amniotic infection is
associated with obstetrical complications such as preterm labor with intact or ruptured …

Management of clinical chorioamnionitis: an evidence-based approach

A Conde-Agudelo, R Romero, EJ Jung… - American journal of …, 2020 - Elsevier
This review aimed to examine the existing evidence about interventions proposed for the
treatment of clinical chorioamnionitis, with the goal of develo** an evidence-based …

Inflammasomes: their role in normal and complicated pregnancies

N Gomez-Lopez, K Motomura, D Miller… - The Journal of …, 2019 - journals.aai.org
Inflammasomes are cytoplasmic multiprotein complexes that coordinate inflammatory
responses, including those that take place during pregnancy. Inflammasomes and their …

Effector and activated T cells induce preterm labor and birth that is prevented by treatment with progesterone

M Arenas-Hernandez, R Romero, Y Xu… - The Journal of …, 2019 - journals.aai.org
Preterm labor commonly precedes preterm birth, the leading cause of perinatal morbidity
and mortality worldwide. Most research has focused on establishing a causal link between …

Maternal and fetal T cells in term pregnancy and preterm labor

D Miller, M Gershater, R Slutsky, R Romero… - Cellular & Molecular …, 2020 - nature.com
Pregnancy is a state of immunological balance during which the mother and the develo**
fetus must tolerate each other while maintaining sufficient immunocompetence to ward off …

[HTML][HTML] Innate immune cells and toll-like receptor–dependent responses at the maternal–fetal interface

A Olmos-Ortiz, P Flores-Espinosa… - International Journal of …, 2019 - mdpi.com
During pregnancy, the placenta, the mother and the fetus exploit several mechanisms in
order to avoid fetal rejection and to maintain an immunotolerant environment throughout …

Are amniotic fluid neutrophils in women with intraamniotic infection and/or inflammation of fetal or maternal origin?

N Gomez-Lopez, R Romero, Y Xu, Y Leng… - American journal of …, 2017 - Elsevier
Background Neutrophils are the most abundant white blood cells found in the amniotic
cavity of women with intraamniotic infection and/or inflammation. The current belief is that …

Human chorionic gonadotropin-mediated immune responses that facilitate embryo implantation and placentation

A Schumacher, AC Zenclussen - Frontiers in Immunology, 2019 - frontiersin.org
Human chorionic gonadotropin (hCG) serves as one of the first signals provided by the
embryo to the mother. Exactly at the time when the first step of the implantation process is …