[HTML][HTML] The RANK–RANKL–OPG system: a multifaceted regulator of homeostasis, immunity, and cancer
D De Leon-Oliva, S Barrena-Blázquez… - Medicina, 2023 - mdpi.com
The RANK–RANKL–OPG system is a complex signaling pathway that plays a critical role in
bone metabolism, mammary epithelial cell development, immune function, and cancer …
bone metabolism, mammary epithelial cell development, immune function, and cancer …
Progesterone receptor signaling mechanisms
Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls
developmental processes and proliferation and differentiation during the reproductive cycle …
developmental processes and proliferation and differentiation during the reproductive cycle …
Akkermansia muciniphila ameliorates acetaminophen-induced liver injury by regulating gut microbial composition and metabolism
J **a, L Lv, B Liu, S Wang, S Zhang, Z Wu… - Microbiology …, 2022 - journals.asm.org
The gut microbiota drives individual sensitivity to excess acetaminophen (APAP)-mediated
hepatotoxicity. It has been reported that the bacterium Akkermansia muciniphila protects …
hepatotoxicity. It has been reported that the bacterium Akkermansia muciniphila protects …
RANKL/RANK/OPG system beyond bone remodeling: involvement in breast cancer and clinical perspectives
Abstract RANKL/RANK/OPG system consists of three essential signaling molecules: i) the
receptor activator of nuclear factor (NF)-kB-ligand (RANKL), ii) the receptor activator of NF …
receptor activator of nuclear factor (NF)-kB-ligand (RANKL), ii) the receptor activator of NF …
Focus on the glycerophosphocholine pathway in choline phospholipid metabolism of cancer
Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which
leads to elevated levels of phosphocholine and glycerophosphocholine in all types of …
leads to elevated levels of phosphocholine and glycerophosphocholine in all types of …
The m6A Reader YTHDF1 Facilitates the Tumorigenesis and Metastasis of Gastric Cancer via USP14 Translation in an m6A-Dependent Manner
XY Chen, R Liang, YC Yi, HN Fan, M Chen… - Frontiers in cell and …, 2021 - frontiersin.org
Objectives N6-methyladenosine (m6A) RNA methylation is implicated in the progression of
multiple cancers via influencing mRNA modification. YTHDF1 can act as an oncogene in …
multiple cancers via influencing mRNA modification. YTHDF1 can act as an oncogene in …
[HTML][HTML] Deep learning–based H-score quantification of immunohistochemistry-stained images
Immunohistochemistry (IHC) is a well-established and commonly used staining method for
clinical diagnosis and biomedical research. In most IHC images, the target protein is …
clinical diagnosis and biomedical research. In most IHC images, the target protein is …
RANK–RANKL signalling in cancer
Oncogenic events combined with a favourable environment are the two main factors in the
oncological process. The tumour microenvironment is composed of a complex …
oncological process. The tumour microenvironment is composed of a complex …
BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways
Y Geng, H Duan, L Xu, N Witman, B Yan, Z Yu… - Communications …, 2021 - nature.com
Bone has a remarkable potential for self-healing and repair, yet several injury types are non-
healing even after surgical or non-surgical treatment. Regenerative therapies that induce …
healing even after surgical or non-surgical treatment. Regenerative therapies that induce …
RETRACTED ARTICLE: Periostin secreted by cancer-associated fibroblasts promotes cancer stemness in head and neck cancer by activating protein tyrosine kinase …
B Yu, K Wu, X Wang, J Zhang, L Wang, Y Jiang… - Cell death & …, 2018 - nature.com
Abstract Protein tyrosine kinase 7 (PTK7) and cancer-associated fibroblasts (CAFs) play
important roles in cancer stemness, respectively. However, little is known about interaction …
important roles in cancer stemness, respectively. However, little is known about interaction …