Constipation is a common problem in patients with advanced cancer and a significant
source of major morbidity and distress, which is often under-appreciated [1]. Constipation is …

The epithelial lining of the gastrointestinal tract serves as the interface for digestion and
absorption of nutrients and water and as a defensive barrier. The defensive functions of the …

The first truly interdisciplinary book on supportive oncology and palliative care returns with a
new edition that serves as a practical guide to the management of the myriad symptoms and …

Opinion statement Cancer-associated pain has traditionally been treated with opioid
analgesics, often in escalating doses. Opioid-induced constipation (OIC) is a common …

Abstract Naldemedine [Symproic®(Japan; USA); Rizmoic®(EU)], an orally available
peripherally acting μ-opioid receptor antagonist (PAMORA), is approved in several countries …

Background When opioid‐induced constipation is treated with centrally acting opioid
antagonists, there may be opioid withdrawal or aggravation of pain due to inhibition of μ …

Objectives: Review the etiology of opioid-induced constipation. Explain the pathophysiology
of opioid-induced constipation. Explain how to prevent opioid-induced constipation. Employ …

Abstract Background & Aim: Opioid induced constipation (OIC) is the most common
side effect of opioid therapy. It can lead to a decreased quality of life. Naldemedine is a …

BackgroundThe serotonin 4 receptor (5-HT4R) is a promising target for the treatment of
depression. Highly selective 5-HT4R agonists, such as prucalopride, have antidepressant …

Pain therapy often entails gastrointestinal adverse events. While opioids are effective drugs
for pain relief, the incidence of opioid-induced constipation (OIC) varies greatly from 15% to …