Traumatic brain injury derived pathological tau polymorphs induce the distinct propagation pattern and neuroinflammatory response in wild type mice

N Puangmalai, N Bhatt, A Bittar, C Jerez… - Progress in …, 2024 - Elsevier
The misfolding and aggregation of the tau protein into neurofibrillary tangles constitutes a
central feature of tauopathies. Traumatic brain injury (TBI) has emerged as a potential risk …

Maternal Med12 safeguards trophoblast pluripotency and placental development

MM Halstead, J Goad, A Khan, R Deshmukh… - bioRxiv, 2024 - biorxiv.org
For a brief but critical period post-fertilization, the mammalian embryo is entirely dependent
on maternal products inherited from the oocyte. Previous research showed that oocyte …

The Role of PI3K-AKT-mTOR Signaling in Neurological Disorder Neurophysiology and Synaptic Plasticity

JK Kushner - 2024 - search.proquest.com
Abstract The PI3K-AKT-mTOR signaling pathway plays a crucial role in neocortical
development and synaptic plasticity. Embryonic mutations along this pathway are implicated …