Brain connectivity in neurodegenerative diseases—from phenotype to proteinopathy

M Pievani, N Filippini, MP Van Den Heuvel… - Nature Reviews …, 2014 - nature.com
Functional and structural connectivity measures, as assessed by means of functional and
diffusion MRI, are emerging as potential intermediate biomarkers for Alzheimer disease (AD) …

Cognitive decline in Parkinson's disease: the complex picture

R Biundo, L Weis, A Antonini - npj Parkinson's Disease, 2016 - nature.com
Mild cognitive impairment (PD-MCI) and dementia (PDD) are among the most frequent non-
motor symptoms in Parkinson's disease (PD). PD-MCI is six times more likely than age …

Multimodal neuroimaging in post-COVID syndrome and correlation with cognition

M Díez-Cirarda, M Yus, N Gómez-Ruiz, C Polidura… - Brain, 2023 - academic.oup.com
Brain changes have been reported in the first weeks after SARS-CoV-2 infection. However,
limited literature exists about brain alterations in post-COVID syndrome, a condition …

Brain iron deposition is linked with cognitive severity in Parkinson's disease

GEC Thomas, LA Leyland, AE Schrag… - Journal of Neurology …, 2020 - jnnp.bmj.com
Background Dementia is common in Parkinson's disease (PD) but measures that track
cognitive change in PD are lacking. Brain tissue iron accumulates with age and co-localises …

Biomarkers for dementia and mild cognitive impairment in Parkinson's disease

M Delgado‐Alvarado, B Gago… - Movement …, 2016 - Wiley Online Library
Cognitive decline is one of the most frequent and disabling nonmotor features of Parkinson's
disease. Around 30% of patients with Parkinson's disease experience mild cognitive …

Brain structural and functional connectivity in P arkinson's disease with freezing of gait

E Canu, F Agosta, E Sarasso, MA Volonte… - Human brain …, 2015 - Wiley Online Library
Objective To use a multimodal approach to assess brain structural pathways and resting
state (RS) functional connectivity abnormalities in patients with Parkinson's disease and …

Gray and white matter imaging: A biomarker for cognitive impairment in early P arkinson's disease?

GW Duncan, MJ Firbank, AJ Yarnall… - Movement …, 2016 - Wiley Online Library
Background The aim of this work was to investigate the cortical and white matter changes
that underlie cognitive impairment in patients with incident Parkinson's disease (PD) disease …

Deep brain stimulation and L-DOPA therapy: concepts of action and clinical applications in Parkinson's disease

M Muthuraman, N Koirala, D Ciolac, B Pintea… - Frontiers in …, 2018 - frontiersin.org
L-DOPA is still the most effective pharmacological therapy for the treatment of motor
symptoms in Parkinson's disease (PD) almost four decades after it was first used. Deep …

Safety and preliminary efficacy of intranasal insulin for cognitive impairment in Parkinson disease and multiple system atrophy: A double-blinded placebo-controlled …

P Novak, DA Pimentel Maldonado, V Novak - PloS one, 2019 - journals.plos.org
Parkinson disease (PD) is associated with cognitive impairment. We aimed to determine the
effects of intranasal insulin (INI) on cognition and motor performance in PD. This was a proof …

Cognitive impairment in Parkinson's disease: An updated overview focusing on emerging pharmaceutical treatment approaches

Y Degirmenci, E Angelopoulou, VE Georgakopoulou… - Medicina, 2023 - mdpi.com
Cognitive impairment in patients with Parkinson's disease (PD) is one of the commonest and
most disabling non-motor manifestations during the course of the disease. The clinical …