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Activated fibroblasts in cancer: Perspectives and challenges
Activated fibroblasts in tumors, or cancer-associated fibroblasts (CAFs), have become a
popular research area over the past decade. As important players in many aspects of tumor …
popular research area over the past decade. As important players in many aspects of tumor …
Fibroblasts in cancer: Unity in heterogeneity
Tumor cells do not exist in isolation in vivo, and carcinogenesis depends on the surrounding
tumor microenvironment (TME), composed of a myriad of cell types and biophysical and …
tumor microenvironment (TME), composed of a myriad of cell types and biophysical and …
[HTML][HTML] Wound healing, fibroblast heterogeneity, and fibrosis
Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …
However, the mechanisms by which they contribute to both physiologic and pathologic …
A single–cell type transcriptomics map of human tissues
Advances in molecular profiling have opened up the possibility to map the expression of
genes in cells, tissues, and organs in the human body. Here, we combined single-cell …
genes in cells, tissues, and organs in the human body. Here, we combined single-cell …
Guidelines for minimal information on cellular senescence experimentation in vivo
Cellular senescence is a cell fate triggered in response to stress and is characterized by
stable cell-cycle arrest and a hypersecretory state. It has diverse biological roles, ranging …
stable cell-cycle arrest and a hypersecretory state. It has diverse biological roles, ranging …
Immune ageing at single-cell resolution
Ageing leads to profound alterations in the immune system and increases susceptibility to
some chronic, infectious and autoimmune diseases. In recent years, widespread application …
some chronic, infectious and autoimmune diseases. In recent years, widespread application …
[HTML][HTML] Focus on the contribution of oxidative stress in skin aging
F Papaccio, S Caputo, B Bellei - Antioxidants, 2022 - mdpi.com
Skin aging is one of the most evident signs of human aging. Modification of the skin during
the life span is characterized by fine lines and wrinkling, loss of elasticity and volume, laxity …
the life span is characterized by fine lines and wrinkling, loss of elasticity and volume, laxity …
Deciphering cell–cell interactions and communication from gene expression
Cell–cell interactions orchestrate organismal development, homeostasis and single-cell
functions. When cells do not properly interact or improperly decode molecular messages …
functions. When cells do not properly interact or improperly decode molecular messages …
Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases
CC Deng, YF Hu, DH Zhu, Q Cheng, JJ Gu… - Nature …, 2021 - nature.com
Fibrotic skin disease represents a major global healthcare burden, characterized by
fibroblast hyperproliferation and excessive accumulation of extracellular matrix. Fibroblasts …
fibroblast hyperproliferation and excessive accumulation of extracellular matrix. Fibroblasts …