The creatine kinase system and pleiotropic effects of creatine
The pleiotropic effects of creatine (Cr) are based mostly on the functions of the enzyme
creatine kinase (CK) and its high-energy product phosphocreatine (PCr). Multidisciplinary …
creatine kinase (CK) and its high-energy product phosphocreatine (PCr). Multidisciplinary …
Mitochondrial dynamics in neuronal injury, development and plasticity
Mitochondria fulfill numerous cellular functions including ATP production, Ca2+ buffering,
neurotransmitter synthesis and degradation, ROS production and sequestration, apoptosis …
neurotransmitter synthesis and degradation, ROS production and sequestration, apoptosis …
Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye
Here we report multiple lines of evidence for a comprehensive model of energy metabolism
in the vertebrate eye. Metabolic flux, locations of key enzymes, and our finding that glucose …
in the vertebrate eye. Metabolic flux, locations of key enzymes, and our finding that glucose …
Retinal metabolism: a comparative look at energetics in the retina
MW Country - Brain research, 2017 - Elsevier
The retina is part of the central nervous system, and shares the characteristically high
metabolism of the brain. The high energy demand of the retina is normally matched with a …
metabolism of the brain. The high energy demand of the retina is normally matched with a …
Glucose, lactate, and shuttling of metabolites in vertebrate retinas
The vertebrate retina has specific functions and structures that give it a unique set of
constraints on the way in which it can produce and use metabolic energy. The retina's …
constraints on the way in which it can produce and use metabolic energy. The retina's …
Lateral interactions in the outer retina
Lateral interactions in the outer retina, particularly negative feedback from horizontal cells to
cones and direct feed-forward input from horizontal cells to bipolar cells, play a number of …
cones and direct feed-forward input from horizontal cells to bipolar cells, play a number of …
Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration
Photoreceptors are the most numerous and metabolically demanding cells in the retina.
Their primary nutrient source is the choriocapillaris, and both the choriocapillaris and …
Their primary nutrient source is the choriocapillaris, and both the choriocapillaris and …
Metabolomics in the study of retinal health and disease
Metabolomics is the qualitative and quantitative assessment of the metabolites (small
molecules< 1.5 kDa) in body fluids. The metabolites are the downstream of the genetic …
molecules< 1.5 kDa) in body fluids. The metabolites are the downstream of the genetic …
Retinal energy demands control vascular supply of the retina in development and disease: The role of neuronal lipid and glucose metabolism
Neuronal energy demands are met by a tightly coupled and adaptive vascular network that
supplies nutrients and oxygen. The retina is one of the highest energy-consuming organs …
supplies nutrients and oxygen. The retina is one of the highest energy-consuming organs …
[HTML][HTML] Quantification of oxygen consumption in retina ex vivo demonstrates limited reserve capacity of photoreceptor mitochondria
Purpose: Cell death in neurodegeneration occurs at the convergence of diverse metabolic
pathways. In the retina, a common underlying mechanism involves mitochondrial …
pathways. In the retina, a common underlying mechanism involves mitochondrial …