Factor H is an essential regulatory protein that plays a critical role in the homeostasis of the
complement system in plasma and in the protection of bystander host cells and tissues from …

Complement is a major defense system of innate immunity and aimed to destroy microbes.
One of the central complement regulators is factor H, which belongs to a protein family that …

Factor H-related protein 5 (FHR-5) is a recently discovered member of the factor H (fH)-
related protein family. FHR proteins are structurally similar to the complement regulator fH …

The early phase of leptospiral infection is characterized by the presence of live organisms in
the blood. Pathogenic Leptospira interrogans is resistant to the alternative pathway of …

Human-pathogenic microbes possess various means to avoid destruction by our immune
system. These include interactions with the host complement system that may facilitate …

The complement system is involved in defense against microorganisms, the processing of
immune complexes and apoptotic debris, and the development of an appropriate immune …

Abstract Background. Isolates of Borrelia burgdorferi, the causative agent of Lyme disease,
express up to 5 distinct complement regulator-acquiring surface proteins (CRASP-1,-2,-3,-4 …

The db/db mouse develops features of type II diabetes mellitus as the result of impaired
signaling through its abnormal leptin receptor. In spite of accurate metabolic features of …

The complement system consists of a number of serum and membrane-bound proteins that
play a crucial role in protecting the host organism against microbial infection. Complement …

Activation of the complement system is tightly regulated by plasma and cell-associated
complement regulatory proteins (CRPs), such as factor H (fH), decay-accelerating factor …