Develo** functional organs from stem cells remains a challenging goal in regenerative
medicine. Existing methodologies, such as tissue engineering, bioprinting, and organoids …

Stem cell-based embryo models offer unprecedented experimental tools for studying early
human development. The usefulness of embryo models hinges on their molecular, cellular …

Transposable elements (TEs), long discounted as 'selfish genomic elements,'are
increasingly appreciated as the drivers of genomic evolution, genome organization, and …

Recently, several studies using cultures of human embryos together with single-cell RNA-
seq analyses have revealed differences between humans and mice, necessitating the study …

Transposable elements (TEs) are parasitic DNA sequences accounting for over half of the
human genome. Tight control of the repression and activation states of TEs is critical for …

With the advancement of human stem cell cultures and interest in understanding human
embryogenesis, human blastocyst-like structures, or human blastoids, are being developed …

Primordial germ cells (PGCs) are the embryonic precursors of sperm and eggs. They
transmit genetic and epigenetic information across generations. Given the prominent role of …

Endogenous retroviruses (ERVs) occupy a significant part of the human genome, with some
encoding proteins that influence the immune system or regulate cell-cell fusion in early extra …

In recent years, the pursuit of inducing the trophoblast stem cell (TSC) state has gained
prominence as a compelling research objective, illuminating the establishment of the …

From deciphering infection and disease mechanisms to identifying novel biomarkers and
personalizing treatments, the characteristics of individual cells can provide significant …