Facing the explosive growth of biological sequence data, such as those of protein/peptide
and DNA/RNA, generated in the post-genomic age, many bioinformatical and mathematical …

The eternal or ultimate goal of medicinal chemistry is to find most effective ways to treat
various diseases and extend human beings' life as long as possible. Human being is a …

Protein-protein interactions (PPIs) play an important role in cell life activities such as
transcriptional regulation, signal transduction and drug signal transduction. The study of …

Abstract N 6-methyladenine (6mA) is one kind of post-replication modification (PTM or
PTRM) occurring in a wide range of DNA sequences. Accurate identification of its sites will …

Cancer remains a major killer worldwide. Traditional methods of cancer treatment are
expensive and have some deleterious side effects on normal cells. Fortunately, the …

Motivation: Enhancers are of short regulatory DNA elements. They can be bound with
proteins (activators) to activate transcription of a gene, and hence play a critical role in …

Occurring at adenine (A) with the consensus motif GAC, N 6-methyladenosine (m 6 A) is one
of the most abundant modifications in RNA, which plays very important roles in many …

There are many different types of RNA modifications, which are essential for numerous
biological processes. Knowledge about the occurrence sites of RNA modifications in its …

Being one type of post-translational modifications (PTMs), protein lysine succinylation is
important in regulating varieties of biological processes. It is also involved with some …

As the most abundant RNA modification, pseudouridine plays important roles in many
biological processes. Occurring at the uridine site and catalyzed by pseudouridine synthase …