Radiation-induced brain injury: a review
D Greene-Schloesser, ME Robbins, AM Peiffer… - Frontiers in …, 2012 - frontiersin.org
Approximately 100,000 primary and metastatic brain tumor patients/year in the US survive
long enough (> 6 months) to experience radiation-induced brain injury. Prior to 1970, the …
long enough (> 6 months) to experience radiation-induced brain injury. Prior to 1970, the …
The biomedical uses of inositols: A nutraceutical approach to metabolic dysfunction in aging and neurodegenerative diseases
Inositols are sugar-like compounds that are widely distributed in nature and are a part of
membrane molecules, participating as second messengers in several cell-signaling …
membrane molecules, participating as second messengers in several cell-signaling …
[HTML][HTML] Anti-satellite glia cell IgG antibodies in fibromyalgia patients are related to symptom severity and to metabolite concentrations in thalamus and rostral anterior …
Recent translational work has shown that fibromyalgia might be an autoimmune condition
with pathogenic mechanisms mediated by a peripheral, pain-inducing action of …
with pathogenic mechanisms mediated by a peripheral, pain-inducing action of …
A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease
Objective: This randomized, double-blind, placebo-controlled, dose-ranging phase 2 study
explored safety, efficacy, and biomarker effects of ELND005 (an oral amyloid anti …
explored safety, efficacy, and biomarker effects of ELND005 (an oral amyloid anti …
A systematic review of brain metabolite changes, measured with 1H magnetic resonance spectroscopy, in healthy aging
KK Haga, YP Khor, A Farrall, JM Wardlaw - Neurobiology of aging, 2009 - Elsevier
BACKGROUND: 1H MR spectroscopy (MRS) can identify metabolite abnormalities in age-
related, neurological diseases. However, there is little information on how metabolites …
related, neurological diseases. However, there is little information on how metabolites …
Regional myo-inositol, creatine, and choline levels are higher at older age and scale negatively with visuospatial working memory: a cross-sectional proton MR …
A Lind, CJ Boraxbekk, ET Petersen… - Journal of …, 2020 - Soc Neuroscience
Proton MR spectroscopy (1H-MRS) has been used to assess regional neurochemical brain
changes during normal ageing, but results have varied. Exploiting the increased sensitivity …
changes during normal ageing, but results have varied. Exploiting the increased sensitivity …
Inducible over‐expression of wild type α‐synuclein in human neuronal cells leads to caspase‐dependent non‐apoptotic death
Alpha‐synuclein (ASYN) is central in Parkinson's disease pathogenesis. Converging pieces
of evidence suggest that the levels of ASYN expression play a critical role in both familial …
of evidence suggest that the levels of ASYN expression play a critical role in both familial …
Properties of scyllo–inositol as a therapeutic treatment of AD-like pathology
D Fenili, M Brown, R Rappaport… - Journal of molecular …, 2007 - Springer
Inositol is a simple polyol with eight naturally occurring stereoisomers. myo–Inositol, D-chiro–
and epi–inositol have been examined as potential therapeutic agents for various diseases …
and epi–inositol have been examined as potential therapeutic agents for various diseases …
[HTML][HTML] Neurometabolic timecourse of healthy aging
Purpose The neurometabolic timecourse of healthy aging is not well-established, in part due
to diversity of quantification methodology. In this study, a large structured cross-sectional …
to diversity of quantification methodology. In this study, a large structured cross-sectional …
Non‐water‐suppressed proton MR spectroscopy improves spectral quality in the human spinal cord
Magnetic resonance spectroscopy enables insight into the chemical composition of spinal
cord tissue. However, spinal cord magnetic resonance spectroscopy has rarely been …
cord tissue. However, spinal cord magnetic resonance spectroscopy has rarely been …