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Accelerating Alzheimer's therapeutic development: the past and future of clinical trials
Alzheimer's disease (AD) research has entered a new era with the recent positive phase 3
clinical trials of the anti-Aβ antibodies lecanemab and donanemab. Why did it take 30 years …
clinical trials of the anti-Aβ antibodies lecanemab and donanemab. Why did it take 30 years …
Is Alzheimer disease a disease?
AD Korczyn, LT Grinberg - Nature Reviews Neurology, 2024 - nature.com
Dementia, a prevalent condition among older individuals, has profound societal
implications. Extensive research has resulted in no cure for what is perceived as the most …
implications. Extensive research has resulted in no cure for what is perceived as the most …
LATE-NC staging in routine neuropathologic diagnosis: an update
An international consensus report in 2019 recommended a classification system for limbic-
predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC) …
predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC) …
A fluid biomarker reveals loss of TDP-43 splicing repression in presymptomatic ALS–FTD
Although loss of TAR DNA-binding protein 43 kDa (TDP-43) splicing repression is well
documented in postmortem tissues of amyotrophic lateral sclerosis (ALS) and frontotemporal …
documented in postmortem tissues of amyotrophic lateral sclerosis (ALS) and frontotemporal …
TDP-43 pathology is associated with increased tau burdens and seeding
SO Tomé, G Tsaka, A Ronisz, S Ospitalieri… - Molecular …, 2023 - Springer
Abstract Background Most Alzheimer's Disease (AD) cases also exhibit limbic predominant
age-related TDP-43 encephalopathy neuropathological changes (LATE-NC), besides …
age-related TDP-43 encephalopathy neuropathological changes (LATE-NC), besides …
The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia
Background Population-based autopsy studies provide valuable insights into the causes of
dementia but are limited by sample size and restriction to specific populations …
dementia but are limited by sample size and restriction to specific populations …
GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia
Genome-wide association studies (GWAS) have identified> 80 Alzheimer's disease and
related dementias (ADRD)-associated genetic loci. However, the clinical outcomes used in …
related dementias (ADRD)-associated genetic loci. However, the clinical outcomes used in …
Loss of TDP-43 splicing repression occurs early in the aging population and is associated with Alzheimer's disease neuropathologic changes and cognitive decline
LATE-NC, the neuropathologic changes of limbic-predominant age-related TAR DNA-
binding protein 43 kDa (TDP-43) encephalopathy are frequently associated with Alzheimer's …
binding protein 43 kDa (TDP-43) encephalopathy are frequently associated with Alzheimer's …
Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer's disease
Nuclear clearance and cytoplasmic accumulations of the RNA-binding protein TDP-43 are
pathological hallmarks in almost all patients with amyotrophic lateral sclerosis (ALS) and up …
pathological hallmarks in almost all patients with amyotrophic lateral sclerosis (ALS) and up …
Repetitive head impacts and chronic traumatic encephalopathy are associated with TDP-43 inclusions and hippocampal sclerosis
R Nicks, NF Clement, VE Alvarez, Y Tripodis… - Acta …, 2023 - Springer
Hippocampal sclerosis (HS) is associated with advanced age as well as transactive
response DNA-binding protein with 43 kDa (TDP-43) deposits. Both hippocampal sclerosis …
response DNA-binding protein with 43 kDa (TDP-43) deposits. Both hippocampal sclerosis …