The rise in antibiotic-resistant bacteria, including strains that are resistant to last-resort
antibiotics, and the limited ability of antibiotics to eradicate biofilms have necessitated the …

There is an urgent global need for new strategies and drugs to control and treat multidrug-
resistant bacterial infections. In 2017, the World Health Organization (WHO) released a list of …

Resistance threatens to render antibiotics—which are essential for modern medicine—
ineffective, thus posing a threat to human health. The discovery of novel classes of …

Staphylococcus aureus is one of the most important human pathogens worldwide. Its high
antibiotic resistance profile reinforces the need for new interventions like vaccines in …

Objective Atopic dermatitis (AD) is a chronic inflammatory skin disease that is complicated
by an increased risk for skin and systemic infections. Preventive therapy for AD is based on …

Over the past few decades, we have witnessed a surge around the world in the emergence
of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and …

Antimicrobial resistance (AMR) has become a global public health issue and antibiotic
agents have lagged behind the rise in bacterial resistance. We are searching for a new …

Endolysins are bacteriophage-encoded enzymes that can specifically degrade the
peptidoglycan layer of bacterial cell wall, making them an attractive tool for the development …

Infections caused by antibiotic-resistant bacteria (ARB) are one of the major global health
challenges of our time. In addition to develo** new antibiotics to combat ARB, sensitizing …

Highlights•Endolysins are promising novel therapeutics for treatment of bacterial
infections.•Endolysins can target infections in different organs and tissues of the human …