Cancer nanomedicine: progress, challenges and opportunities

J Shi, PW Kantoff, R Wooster, OC Farokhzad - Nature reviews cancer, 2017 - nature.com
The intrinsic limits of conventional cancer therapies prompted the development and
application of various nanotechnologies for more effective and safer cancer treatment …

A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics

SD Steichen, M Caldorera-Moore… - European journal of …, 2013 - Elsevier
The tumor microenvironment provides unique challenges for the delivery of
chemotherapeutic agents in doses that are effective while ensuring minimal systemic …

Emerging role of hydrogels in drug delivery systems, tissue engineering and wound management

S Jacob, AB Nair, J Shah, N Sreeharsha, S Gupta… - Pharmaceutics, 2021 - mdpi.com
The popularity of hydrogels as biomaterials lies in their tunable physical properties, ability to
encapsulate small molecules and macromolecular drugs, water holding capacity, flexibility …

Advanced engineered nanoparticulate platforms to address key biological barriers for delivering chemotherapeutic agents to target sites

J Cao, D Huang, NA Peppas - Advanced drug delivery reviews, 2020 - Elsevier
The widespread development of nanocarriers to deliver chemotherapeutics to specific tumor
sites has been motivated by the lack of selective targeting during chemotherapy inducing …

Hydrogels and scaffolds for immunomodulation

A Singh, NA Peppas - Advanced materials, 2014 - Wiley Online Library
For over two decades, immunologists and biomaterials scientists have co‐existed in parallel
world with the rationale of understanding the molecular profile of immune responses to …

Therapeutic applications of hydrogels in oral drug delivery

LA Sharpe, AM Daily, SD Horava… - Expert opinion on drug …, 2014 - Taylor & Francis
Introduction: Oral delivery of therapeutics, particularly protein-based pharmaceutics, is of
great interest for safe and controlled drug delivery for patients. Hydrogels offer excellent …

Nexus between in silico and in vivo models to enhance clinical translation of nanomedicine

FM Kashkooli, M Soltani, M Souri, C Meaney… - Nano Today, 2021 - Elsevier
In cancer, one of the main barriers to effective chemotherapy is inefficient drug delivery. The
delivery of drugs to solid tumors involves various biochemical, biophysical, and mechanical …

Soft‐nanoparticle functionalization of natural hydrogels for tissue engineering applications

K Elkhoury, CS Russell… - Advanced …, 2019 - Wiley Online Library
Tissue engineering has emerged as an important research area that provides numerous
research tools for the fabrication of biologically functional constructs that can be used in drug …

Nanoparticle delivery systems for cancer therapy: advances in clinical and preclinical research

SP Egusquiaguirre, M Igartua, RM Hernández… - Clinical and …, 2012 - Springer
Conventional anticancer drugs display significant shortcomings which limit their use in
cancer therapy. For this reason, important progress has been achieved in the field of …

Responsive theranostic systems: integration of diagnostic imaging agents and responsive controlled release drug delivery carriers

ME Caldorera-Moore, WB Liechty… - Accounts of chemical …, 2011 - ACS Publications
For decades, researchers and medical professionals have aspired to develop mechanisms
for noninvasive treatment and monitoring of pathological conditions within the human body …