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Physics-constrained deep active learning for spatiotemporal modeling of cardiac electrodynamics
The development of computational modeling and simulation have immensely benefited the
study of cardiac disease mechanisms and facilitated the optimal disease diagnosis and …
study of cardiac disease mechanisms and facilitated the optimal disease diagnosis and …
A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis
We present a novel computational model for maladaptive cardiac growth in which kinematic
changes of the cardiac chambers are attributed to alterations in cytoskeletal architecture and …
changes of the cardiac chambers are attributed to alterations in cytoskeletal architecture and …
Electromechanics of the heart: a unified approach to the strongly coupled excitation–contraction problem
This manuscript is concerned with a novel, unified finite element approach to fully coupled
cardiac electromechanics. The intrinsic coupling arises from both the excitation-induced …
cardiac electromechanics. The intrinsic coupling arises from both the excitation-induced …
In vivo cardiac phase response curve elucidates human respiratory heart rate variability
B Kralemann, M Frühwirth, A Pikovsky… - Nature …, 2013 - nature.com
Recovering interaction of endogenous rhythms from observations is challenging, especially
if a mathematical model explaining the behaviour of the system is unknown. The decisive …
if a mathematical model explaining the behaviour of the system is unknown. The decisive …
Generating Purkinje networks in the human heart
FS Costabal, DE Hurtado, E Kuhl - Journal of biomechanics, 2016 - Elsevier
The Purkinje network is an integral part of the excitation system in the human heart. Yet, to
date, there is no in vivo imaging technique to accurately reconstruct its geometry and …
date, there is no in vivo imaging technique to accurately reconstruct its geometry and …
[HTML][HTML] Machine learning in drug development: Characterizing the effect of 30 drugs on the QT interval using Gaussian process regression, sensitivity analysis, and …
FS Costabal, K Matsuno, J Yao, P Perdikaris… - Computer Methods in …, 2019 - Elsevier
Prolonged QT intervals are a major risk factor for ventricular arrhythmias and a leading
cause of sudden cardiac death. Various drugs are known to trigger QT interval prolongation …
cause of sudden cardiac death. Various drugs are known to trigger QT interval prolongation …
A generic approach towards finite growth with examples of athlete's heart, cardiac dilation, and cardiac wall thickening
The objective of this work is to establish a generic continuum-based computational concept
for finite growth of living biological tissues. The underlying idea is the introduction of an …
for finite growth of living biological tissues. The underlying idea is the introduction of an …
Computational modeling of passive myocardium
S Göktepe, SNS Acharya, J Wong… - International Journal for …, 2011 - Wiley Online Library
This work deals with the computational modeling of passive myocardial tissue within the
framework of mixed, non‐linear finite element methods. We consider a recently proposed …
framework of mixed, non‐linear finite element methods. We consider a recently proposed …
Computational modeling of growth: systemic and pulmonary hypertension in the heart
We introduce a novel constitutive model for growing soft biological tissue and study its
performance in two characteristic cases of mechanically induced wall thickening of the heart …
performance in two characteristic cases of mechanically induced wall thickening of the heart …
The importance of mechano-electrical feedback and inertia in cardiac electromechanics
FS Costabal, FA Concha, DE Hurtado, E Kuhl - Computer methods in …, 2017 - Elsevier
In the past years, a number of cardiac electromechanics models have been developed to
better understand the excitation–contraction behavior of the heart. However, there is no …
better understand the excitation–contraction behavior of the heart. However, there is no …