Cholangiocarcinoma 2020: the next horizon in mechanisms and management
JM Banales, JJG Marin, A Lamarca… - Nature reviews …, 2020 - nature.com
Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant
tumours that can arise at any point of the biliary tree. Their incidence is increasing globally …
tumours that can arise at any point of the biliary tree. Their incidence is increasing globally …
Liver cancer cell of origin, molecular class, and effects on patient prognosis
Primary liver cancer is the second leading cause of cancer-related death worldwide and
therefore a major public health challenge. We review hypotheses of the cell of origin of liver …
therefore a major public health challenge. We review hypotheses of the cell of origin of liver …
Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study
GK Abou-Alfa, T Macarulla, MM Javle… - The Lancet …, 2020 - thelancet.com
Summary Background Isocitrate dehydrogenase 1 (IDH1) mutations occur in approximately
13% of patients with intrahepatic cholangiocarcinoma, a relatively uncommon cancer with a …
13% of patients with intrahepatic cholangiocarcinoma, a relatively uncommon cancer with a …
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
Detection of somatic point substitutions is a key step in characterizing the cancer genome.
However, existing methods typically miss low-allelic-fraction mutations that occur in only a …
However, existing methods typically miss low-allelic-fraction mutations that occur in only a …
Cholangiocarcinoma
Cholangiocarcinoma represents a diverse group of epithelial cancers united by late
diagnosis and poor outcomes. Specific diagnostic and therapeutic approaches are …
diagnosis and poor outcomes. Specific diagnostic and therapeutic approaches are …
Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of …
JM Banales, V Cardinale, G Carpino… - Nature reviews …, 2016 - research.ed.ac.uk
Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies with features of
biliary tract differentiation. CCA is the second most common primary liver tumour and the …
biliary tract differentiation. CCA is the second most common primary liver tumour and the …
[HTML][HTML] Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma
Cholangiocarcinoma (CCA) comprises a heterogeneous group of cancers with pathologic
features of biliary tract differentiation, and is presumed to arise from the intra-or extrahepatic …
features of biliary tract differentiation, and is presumed to arise from the intra-or extrahepatic …
The implications of IDH mutations for cancer development and therapy
Mutations in the genes encoding the cytoplasmic and mitochondrial forms of isocitrate
dehydrogenase (IDH1 and IDH2, respectively; collectively referred to as IDH) are frequently …
dehydrogenase (IDH1 and IDH2, respectively; collectively referred to as IDH) are frequently …
Whole-genome and epigenomic landscapes of etiologically distinct subtypes of cholangiocarcinoma
Cholangiocarcinoma (CCA) is a hepatobiliary malignancy exhibiting high incidence in
countries with endemic liver-fluke infection. We analyzed 489 CCAs from 10 countries …
countries with endemic liver-fluke infection. We analyzed 489 CCAs from 10 countries …
Pathogenesis, diagnosis, and management of cholangiocarcinoma
SI Ilyas, GJ Gores - Gastroenterology, 2013 - Elsevier
Cholangiocarcinomas (CCAs) are hepatobiliary cancers with features of cholangiocyte
differentiation; they can be classified anatomically as intrahepatic CCA (iCCA), perihilar …
differentiation; they can be classified anatomically as intrahepatic CCA (iCCA), perihilar …