Why nature really chose phosphate
Phosphoryl transfer plays key roles in signaling, energy transduction, protein synthesis, and
maintaining the integrity of the genetic material. On the surface, it would appear to be a …
maintaining the integrity of the genetic material. On the surface, it would appear to be a …
Biological phosphoryl-transfer reactions: understanding mechanism and catalysis
JK Lassila, JG Zalatan… - Annual review of …, 2011 - annualreviews.org
Phosphoryl-transfer reactions are central to biology. These reactions also have some of the
slowest nonenzymatic rates and thus require enormous rate accelerations from biological …
slowest nonenzymatic rates and thus require enormous rate accelerations from biological …
Enzymatic mechanisms of phosphate and sulfate transfer
WW Cleland, AC Hengge - Chemical reviews, 2006 - ACS Publications
Many biological molecules contain phosphate or sulfate, and the enzymatic reactions that
transfer these groups play important roles in metabolism. DNA and RNA are phosphate …
transfer these groups play important roles in metabolism. DNA and RNA are phosphate …
Metal complexes of organophosphate esters and open-framework metal phosphates: synthesis, structure, transformations, and applications
Phosphorus is a vital element both in living matter and in the Earth's crust. The human body
contains about 1% by weight of the element phosphorus, about 4/5 of this being present as …
contains about 1% by weight of the element phosphorus, about 4/5 of this being present as …
Progress in artificial metallonucleases
The development of synthetic agents able to hydrolytically cleave DNA with high efficiency
and selectivity is still a fascinating challenge. Over the years, many examples have been …
and selectivity is still a fascinating challenge. Over the years, many examples have been …
Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps
Catalysis by protein-tyrosine phosphatase 1B (PTP1B) occurs through a two-step
mechanism involving a phosphocysteine intermediate. We have solved crystal structures for …
mechanism involving a phosphocysteine intermediate. We have solved crystal structures for …
Phosphate forms an unusual tripodal complex with the Fe–Mn center of sweet potato purple acid phosphatase
G Schenk, LR Gahan, LE Carrington… - Proceedings of the …, 2005 - National Acad Sciences
Purple acid phosphatases (PAPs) are a family of binuclear metalloenzymes that catalyze the
hydrolysis of phosphoric acid esters and anhydrides. A PAP in sweet potato has a unique …
hydrolysis of phosphoric acid esters and anhydrides. A PAP in sweet potato has a unique …
Experimental and computational analysis of the transition state for ribonuclease A-catalyzed RNA 2′-O-transphosphorylation
Enzymes function by stabilizing reaction transition states; therefore, comparison of the
transition states of enzymatic and nonenzymatic model reactions can provide insight into …
transition states of enzymatic and nonenzymatic model reactions can provide insight into …
Efficient hydrolytic cleavage of plasmid DNA by chloro-cobalt (II) complexes based on sterically hindered pyridyl tripod tetraamine ligands: Synthesis, crystal structure …
SS Massoud, RS Perkins, FR Louka, W Xu… - Dalton …, 2014 - pubs.rsc.org
Four new cobalt (II) complexes [Co (6-MeTPA) Cl] ClO4/PF6 (2/2a),[Co (6-Me2TPA) Cl]
ClO4/PF6 (3/3a),[Co (BPQA) Cl] ClO4/PF6 (4/4a) and [Co (BQPA) Cl] ClO4/PF6 (5/5a) as …
ClO4/PF6 (3/3a),[Co (BPQA) Cl] ClO4/PF6 (4/4a) and [Co (BQPA) Cl] ClO4/PF6 (5/5a) as …
Are mixed explicit/implicit solvation models reliable for studying phosphate hydrolysis? A comparative study of continuum, explicit and mixed solvation models
Are all solvation models equal? An in‐depth comparison of mixed implicit/explicit solvation
models shows that while both the implicit and explicit (QM/MM–FEP) solvation models can …
models shows that while both the implicit and explicit (QM/MM–FEP) solvation models can …