Adeno-associated virus toolkit to target diverse brain cells
Recombinant adeno-associated viruses (AAVs) are commonly used gene delivery vehicles
for neuroscience research. They have two engineerable features: the capsid (outer protein …
for neuroscience research. They have two engineerable features: the capsid (outer protein …
Viral tools for neuroscience
Recombinant viruses are the workhorse of modern neuroscience. Whether one would like to
understand a neuron's morphology, natural activity patterns, molecular composition …
understand a neuron's morphology, natural activity patterns, molecular composition …
Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans
Recent success in identifying gene-regulatory elements in the context of recombinant adeno-
associated virus vectors has enabled cell-type-restricted gene expression. However, within …
associated virus vectors has enabled cell-type-restricted gene expression. However, within …
Spatial transcriptomics for profiling the tropism of viral vectors in tissues
A barrier to advancing engineered adeno-associated viral vectors (AAVs) for precision
access to cell subtypes is a lack of high-throughput, high-resolution assays to characterize in …
access to cell subtypes is a lack of high-throughput, high-resolution assays to characterize in …
[HTML][HTML] Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex
Viral genetic tools that target specific brain cell types could transform basic neuroscience
and targeted gene therapy. Here, we use comparative open chromatin analysis to identify …
and targeted gene therapy. Here, we use comparative open chromatin analysis to identify …
Non-linear dimensionality reduction on extracellular waveforms reveals cell type diversity in premotor cortex
Cortical circuits are thought to contain a large number of cell types that coordinate to
produce behavior. Current in vivo methods rely on clustering of specified features of …
produce behavior. Current in vivo methods rely on clustering of specified features of …
Local feedback inhibition tightly controls rapid formation of hippocampal place fields
Hippocampal place cells underlie spatial navigation and memory. Remarkably, CA1
pyramidal neurons can form new place fields within a single trial by undergoing rapid …
pyramidal neurons can form new place fields within a single trial by undergoing rapid …
Mesoscopic calcium imaging in a head-unrestrained male non-human primate using a lensless microscope
Mesoscopic calcium imaging enables studies of cell-type specific neural activity over large
areas. A growing body of literature suggests that neural activity can be different when …
areas. A growing body of literature suggests that neural activity can be different when …
Sexually divergent mortality and partial phenotypic rescue after gene therapy in a mouse model of Dravet syndrome
Dravet syndrome (DS) is a neurodevelopmental genetic disorder caused by mutations in the
SCN1A gene encoding the α subunit of the NaV1. 1 voltage-gated sodium channel that …
SCN1A gene encoding the α subunit of the NaV1. 1 voltage-gated sodium channel that …
Cellular correlates of gray matter volume changes in magnetic resonance morphometry identified by two-photon microscopy
L Asan, C Falfan-Melgoza, CA Beretta, M Sack… - Scientific Reports, 2021 - nature.com
Magnetic resonance imaging (MRI) of the brain combined with voxel-based morphometry
(VBM) revealed changes in gray matter volume (GMV) in various disorders. However, the …
(VBM) revealed changes in gray matter volume (GMV) in various disorders. However, the …