In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

In the last two decades, solid-state nuclear magnetic resonance (ssNMR) spectroscopy has
transformed from a spectroscopic technique investigating small molecules and industrial …

In recent decades, strategies involving transition-metal catalyzed carbon-carbon or carbon-
heteroatom bond coupling have emerged as potent synthetic tools for constructing intricate …

Hydroamination facilitated by metal hydride catalysis is an appealing synthetic approach to
access valuable nitrogen-containing compounds from readily available unsaturated …

Protein-ligand interactions are at the heart of drug discovery research. NMR spectroscopy is
an excellent technology to identify and validate protein-ligand interactions. A plethora of …

Herein, we report a photoinduced transition-metal-free C (aryl)–N bond formation between
2, 4, 6-tri (aryl) boroxines or arylboronic acids as an aryl source and 1, 4, 2-dioxazol-5-ones …

Baculovirus-infected insect cells have become a powerful tool to express recombinant
proteins for structural and functional studies by NMR spectroscopy. This article provides an …

Heterologous expression of proteins in insect cells is frequently used for crystallographic
structural studies due to the high yields even for challenging proteins requiring the …

Background Once integrated in the genome of infected cells, HIV-1 provirus is transcribed by
the cellular transcription machinery. This process is regulated by both viral and cellular …

For a wide range of proteins of high interest, the major obstacle for NMR studies is the lack
of an affordable eukaryotic expression system for isotope labeling. Here, a simple and …