Transport of ions through pores in membranes is a process of fundamental importance to
cell biology. In living organisms, such transport is facilitated by ion channels that utilize the …

Potassium channels are tetrameric membrane proteins that selectively conduct K+ across
cellular membranes. With 78 family members, K+ channels make up about half of the …

A theoretical framework is elaborated to account for the effect of a transmembrane potential
in computer simulations. It is shown that a simulation with a constant external electric field …

Protein diffusion in lipid membranes is a key aspect of many cellular signaling processes. To
quantitatively describe protein diffusion in membranes, several competing theoretical …

Droplet interface bilayers (DIBs) form between two lipid monolayer-encased aqueous
droplets submerged in oil. Both major structural classes of membrane proteins, α-helix …

HCN1-4 channels are the molecular determinants of the If/Ih current that crucially regulates
cardiac and neuronal cell excitability. HCN dysfunctions lead to sinoatrial block (HCN4) …

Quaternary ammonium blockers were previously shown to bind in the pore to block both
open and closed conformations of large-conductance calcium-activated potassium (BK and …

Potassium (K+) channels are a widespread superfamily of integral membrane proteins that
mediate selective transport of K+ ions through the cell membrane. They have been found in …

Ion channels are signal transduction molecules that switch ion permeation pathways on and
off (gating). Crystal structures of several kinds of potassium channels have revealed open …

1, 4-Dihydropyridines (DHPs) constitute a major class of ligands for L-type Ca 2+ channels
(LTCC). The DHPs have a boat-like, six-membered ring with an NH group at the stern, an …