The expression of the human Ki‐67 protein is strictly associated with cell proliferation.
During interphase, the antigen can be exclusively detected within the nucleus, whereas in …

Simple Summary Cellular proliferation is a central determinant of breast cancer recurrence
risk and response to chemotherapy. The discovery of the Ki-67 antibody by Dr. Johannes …

Eukaryotic genomes are partitioned into chromosomes that form compact and spatially well-
separated mechanical bodies during mitosis,,. This enables chromosomes to move …

The Hippo pathway regulates organ size and tissue homeostasis in response to multiple
stimuli, including cell density and mechanotransduction. Pharmacological inhibition of …

Ki-67 is one of the most famous marker proteins used by histologists to identify proliferating
cells. Indeed, over 30 000 articles referring to Ki-67 are listed on PubMed. Here, we review …

We have identified the yeast and human homologs of the SKP1 gene as a suppressor of
cdc4 mutants and as a cyclin F–binding protein. Skp1p indirectly binds cyclin A/Cdk2 …

In response to DNA damage and replication blocks, cells prevent cell cycle progression
through the control of critical cell cycle regulators. We identified Chk2, the mammalian …

Among the various databases dedicated to the identification of protein families and domains,
PROSITE is the first one created and has continuously evolved since. PROSITE currently …

The helix-turn-helix (HTH) domain is a common denominator in basal and specific
transcription factors from the three super-kingdoms of life. At its core, the domain comprises …

Transcription factors are modular proteins where distinct functions, such as DNA binding,
trans-activation or trans-repression, are often contained within separable domains. DNA …