Nitric oxide (NO) can bind to and inhibit the terminal enzyme of the mitochondrial respiratory
chain, cytochrome c oxidase (complex IV). In vivo, NO is made by the NO synthase (NOS) …

Introduction 3. Mitochondrial dysfunction and the parkinsonian syndrome 4. Mitochondria as
target of environmental toxics 5. Mitochondrial production of free radicals 6. Toxicans …

The mitochondrial mass of rat brain and liver remained unchanged on aging in young
adults, old adults, and senescent animals (28, 60, and 92 wk of age); the values were 15–17 …

Male mice receiving vitamin E (5.0 g α-tocopherol acetate/kg of food) from 28 wk of age
showed a 40% increased median life span, from 61±4 wk to 85±4 wk, and 17% increased …

Frontal cortex samples from frozen human brains were used to assess tissue respiration;
content of mitochondria; mitochondrial oxygen uptake; activity of respiratory complexes and …

It is more than 10 years now that mitochondria are suspected to be sources of nitric oxide
(NO). This hypothesis is intriguing since NO has multiple targets within the organelle and it is …

Paraquat is a highly toxic quaternary nitrogen herbicide capable of increasing superoxide
anion production. The aim of this research was to evaluate various behavioral changes and …

Hippocampus mitochondrial dysfunction with impaired electron transfer and increased
oxidative damage was observed upon rat aging. Hippocampal mitochondria of aged (12 mo) …

Mitochondria isolated from rat heart, liver, kidney and brain (respiratory control 4.0–6.5)
release NO and H2O2 at rates that depend on the mitochondrial metabolic state: releases …

The mitochondrial metabolic state regulates the rate of NO release from coupled
mitochondria: NO release by heart, liver and kidney mitochondria was about 40–45% lower …