Immunoinformatics and vaccine development: an overview

AN Oli, WO Obialor, MO Ifeanyichukwu… - ImmunoTargets and …, 2020 - Taylor & Francis
The use of vaccines have resulted in a remarkable improvement in global health. It has
saved several lives, reduced treatment costs and raised the quality of animal and human …

Multiepitope-based subunit vaccine design and evaluation against respiratory syncytial virus using reverse vaccinology approach

M Tahir ul Qamar, Z Shokat, I Muneer, UA Ashfaq… - Vaccines, 2020 - mdpi.com
Respiratory syncytial virus (RSV) is primarily associated with respiratory disorders globally.
Despite the availability of information, there is still no competitive vaccine available for RSV …

Targeting tumor lineage plasticity in hepatocellular carcinoma using an anti-CLDN6 antibody-drug conjugate

FE Kong, GM Li, YQ Tang, SY **, JHC Loong… - Science Translational …, 2021 - science.org
Tumor lineage plasticity is emerging as a critical mechanism of therapeutic resistance and
tumor relapse. Highly plastic tumor cells can undergo phenotypic switching to a drug …

Differential regulation of Na+ transporters along nephron during ANG II-dependent hypertension: distal stimulation counteracted by proximal inhibition

MTX Nguyen, DH Lee, E Delpire… - American Journal of …, 2013 - journals.physiology.org
During angiotensin II (ANG II)-dependent hypertension, ANG II stimulates, while
hypertension inhibits, Na+ transporter activity to balance Na+ output to input. This study tests …

Protection by hydroxychloroquine prevents placental injury in obstetric antiphospholipid syndrome

J Liu, L Zhang, Y Tian, S Wan, M Hu… - Journal of Cellular …, 2022 - Wiley Online Library
Obstetric antiphospholipid syndrome (OAPS) is mediated by antiphospholipid antibodies
(aPLs, and anti‐β2 glycoprotein I antibody is the main pathogenic antibody), and recurrent …

Intracellular growth of Brucella is mediated by Dps‐dependent activation of ferritinophagy

HT Hop, TXN Huy, HJ Lee, S Kim - EMBO reports, 2023 - embopress.org
Bacteria of the genus Brucella cause brucellosis, one of the world's most common zoonotic
diseases. A major contributor to Brucella's virulence is the ability to circumvent host immune …

Peptide antibodies in clinical laboratory diagnostics

NH Trier, G Houen - Advances in clinical chemistry, 2017 - Elsevier
Peptide antibodies, with their high specificities and affinities, are invaluable reagents for
peptide and protein recognition in biological specimens. Depending on the application and …

[HTML][HTML] Aberrant protein expression of Appl1, Sortilin and Syndecan-1 during the biological progression of prostate cancer

C Martini, JM Logan, A Sorvina, C Gordon, AR Beck… - Pathology, 2023 - Elsevier
Diagnosis and assessment of patients with prostate cancer is dependent on accurate
interpretation and grading of histopathology. However, morphology does not necessarily …

Human intelectin-1 (ITLN1) genetic variation and intestinal expression

EB Nonnecke, PA Castillo, AE Dugan, F Almalki… - Scientific reports, 2021 - nature.com
Intelectins are ancient carbohydrate binding proteins, spanning chordate evolution and
implicated in multiple human diseases. Previous GWAS have linked SNPs in ITLN1 (also …

Specialized stellate cells offer a privileged route for rapid water flux in Drosophila renal tubule

P Cabrero, S Terhzaz, AJ Dornan… - Proceedings of the …, 2020 - National Acad Sciences
Insects are highly successful, in part through an excellent ability to osmoregulate. The renal
(Malpighian) tubules can secrete fluid faster on a per-cell basis than any other epithelium …