Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures
RE Randall, S Goodbourn - Journal of general virology, 2008 - microbiologyresearch.org
The interferon (IFN) system is an extremely powerful antiviral response that is capable of
controlling most, if not all, virus infections in the absence of adaptive immunity. However …
controlling most, if not all, virus infections in the absence of adaptive immunity. However …
The multifunctional NS1 protein of influenza A viruses
The non-structural (NS1) protein of influenza A viruses is a non-essential virulence factor
that has multiple accessory functions during viral infection. In recent years, the major role …
that has multiple accessory functions during viral infection. In recent years, the major role …
Reverse zoonosis of influenza to swine: new perspectives on the human–animal interface
MI Nelson, AL Vincent - Trends in microbiology, 2015 - cell.com
The origins of the 2009 influenza A (H1N1) pandemic in swine are unknown, highlighting
gaps in our understanding of influenza A virus (IAV) ecology and evolution. We review how …
gaps in our understanding of influenza A virus (IAV) ecology and evolution. We review how …
Swine influenza virus: Current status and challenge
W Ma - Virus research, 2020 - Elsevier
Since swine influenza virus was first isolated in 1930, it has become endemic in pigs
worldwide. Although large amount of swine influenza vaccines has been used in swine …
worldwide. Although large amount of swine influenza vaccines has been used in swine …
Swine influenza viruses: a North American perspective
AL Vincent, W Ma, KM Lager, BH Janke… - Advances in virus …, 2008 - Elsevier
Influenza is a zoonotic viral disease that represents a health and economic threat to both
humans and animals worldwide. Swine influenza (SI) was first recognized clinically in pigs …
humans and animals worldwide. Swine influenza (SI) was first recognized clinically in pigs …
Porcine reproductive and respiratory syndrome virus nonstructural protein 1β modulates host innate immune response by antagonizing IRF3 activation
Porcine reproductive and respiratory syndrome virus (PRRSV) infection of swine leads to a
serious disease characterized by a delayed and defective adaptive immune response. It is …
serious disease characterized by a delayed and defective adaptive immune response. It is …
Influenza A virus in swine: epidemiology, challenges and vaccination strategies
Influenza A viruses cause acute respiratory infections in swine that result in significant
economic losses for global pig production. Currently, three different subtypes of influenza A …
economic losses for global pig production. Currently, three different subtypes of influenza A …
The NS1 protein: a multitasking virulence factor
J Ayllon, A García-Sastre - Influenza Pathogenesis and Control-Volume II, 2014 - Springer
The non-structural protein 1 of influenza virus (NS1) is a relatively small polypeptide with an
outstanding number of ascribed functions. NS1 is the main viral antagonist of the innate …
outstanding number of ascribed functions. NS1 is the main viral antagonist of the innate …
Coronavirus non-structural protein 1 is a major pathogenicity factor: implications for the rational design of coronavirus vaccines
R Züst, L Cervantes-Barragán, T Kuri, G Blakqori… - PLoS …, 2007 - journals.plos.org
Attenuated viral vaccines can be generated by targeting essential pathogenicity factors. We
report here the rational design of an attenuated recombinant coronavirus vaccine based on …
report here the rational design of an attenuated recombinant coronavirus vaccine based on …
Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 highly pathogenic avian influenza
Due to the high mortality associated with recent, widely circulating strains of H5N1 influenza
virus in poultry, the recurring introduction of H5N1 viruses from birds to humans, and the …
virus in poultry, the recurring introduction of H5N1 viruses from birds to humans, and the …