Progress on Ras/MAPK signaling research and targeting in blood and solid cancers

M Dillon, A Lopez, E Lin, D Sales, R Perets, P Jain - Cancers, 2021 - mdpi.com
Simple Summary The Ras-Raf-MEK-ERK signaling pathway is responsible for regulating
cell proliferation, differentiation, and survival. Overexpression and overactivation of …

HTLV-1 infection and adult T-cell leukemia/lymphoma—a tale of two proteins: tax and HBZ

CZ Giam, OJ Semmes - Viruses, 2016 - mdpi.com
HTLV-1 (Human T-cell lymphotropic virus type 1) is a complex human delta retrovirus that
currently infects 10–20 million people worldwide. While HTLV-1 infection is generally …

Voluntary driven exoskeleton as a new tool for rehabilitation in chronic spinal cord injury: a pilot study

M Aach, O Cruciger, M Sczesny-Kaiser, O Höffken… - The Spine Journal, 2014 - Elsevier
Background context Treadmill training after traumatic spinal cord injury (SCI) has become an
established therapy to improve walking capabilities. The hybrid assistive limb (HAL) …

Increased glucose metabolic activity is associated with CD4+ T-cell activation and depletion during chronic HIV infection

CS Palmer, M Ostrowski, M Gouillou, L Tsai, DI Yu… - Aids, 2014 - journals.lww.com
Objectives: Glucose metabolism plays a fundamental role in supporting the growth,
proliferation and effector functions of T cells. We investigated the impact of HIV infection on …

HTLV-1, the other pathogenic yet neglected human retrovirus: from transmission to therapeutic treatment

N Futsch, R Mahieux, H Dutartre - Viruses, 2017 - mdpi.com
Going back to their discovery in the early 1980s, both the Human T-cell Leukemia virus type-
1 (HTLV-1) and the Human Immunodeficiency Virus type-1 (HIV-1) greatly fascinated the …

Molecular mechanisms of HTLV-1 cell-to-cell transmission

C Gross, AK Thoma-Kress - Viruses, 2016 - mdpi.com
The tumorvirus human T-cell lymphotropic virus type 1 (HTLV-1), a member of the delta-
retrovirus family, is transmitted via cell-containing body fluids such as blood products …

HIV-1 and HTLV-1 transmission modes: Mechanisms and importance for virus spread

S Kalinichenko, D Komkov, D Mazurov - Viruses, 2022 - mdpi.com
So far, only two retroviruses, human immunodeficiency virus (HIV)(type 1 and 2) and human
T-cell lymphotropic virus type 1 (HTLV-1), have been recognized as pathogenic for humans …

Pathways of cell-cell transmission of HTLV-1

C Pique, KS Jones - Frontiers in microbiology, 2012 - frontiersin.org
The deltaretroviruses human T cell lymphotropic virus type 1 (HTLV-1) and human T cell
lymphotropic virus type 2 (HTLV-2) have long been believed to differ from retroviruses in …

[PDF][PDF] Targeting the C-type lectins-mediated host-pathogen interactions with dextran

S Pustylnikov, D Sagar, P Jain… - Journal of Pharmacy & …, 2014 - frontierspartnerships.org
Dextran, the α-1, 6-linked glucose polymer widely used in biology and medicine, promises
new applications. Linear dextran applied as a blood plasma substitute demonstrates a high …

Co-Infection and Cancer: Host–Pathogen Interaction between Dendritic Cells and HIV-1, HTLV-1, and Other Oncogenic Viruses

TH Mulherkar, DJ Gómez, G Sandel, P Jain - Viruses, 2022 - mdpi.com
Dendritic cells (DCs) function as a link between innate and adaptive immune responses.
Retroviruses HIV-1 and HTLV-1 modulate DCs to their advantage and utilize them to …