Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Neuromuscular disorders comprise a diverse group of human inborn diseases that arise
from defects in the structure and/or function of the muscle tissue—encompassing the muscle …

The ryanodine receptors (RyRs) are high-conductance intracellular Ca2+ channels that play
a pivotal role in the excitation–contraction coupling of skeletal and cardiac muscles. RyRs …

Ryanodine receptors (RyRs) are located in the sarcoplasmic/endoplasmic reticulum
membrane and are responsible for the release of Ca2+ from intracellular stores during …

Inositol trisphosphate is a second messenger that controls many cellular processes by
generating internal calcium signals. It operates through receptors whose molecular and …

Spontaneous local increases in the concentration of intracellular calcium, called" calcium
sparks," were detected in quiescent rat heart cells with a laser scanning confocal …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

Malignant hyperthermia (MH) causes neurological, liver, and kidney damage and death in
humans and major economic losses in the swine industry. A single point mutation in the …

Large-conductance Ca2+ release channels known as ryanodine receptors (RyRs) mediate
the release of Ca2+ from an intracellular membrane compartment, the endo/sarcoplasmic …