Hydrogels for the repair of articular cartilage defects
The repair of articular cartilage defects remains a significant challenge in orthopedic
medicine. Hydrogels, three-dimensional polymer networks swollen in water, offer a unique …
medicine. Hydrogels, three-dimensional polymer networks swollen in water, offer a unique …
3D spatiotemporal mechanical microenvironment: a hydrogel‐based platform for guiding stem cell fate
Y Ma, M Lin, G Huang, Y Li, S Wang, G Bai… - Advanced …, 2018 - Wiley Online Library
Stem cells hold great promise for widespread biomedical applications, for which stem cell
fate needs to be well tailored. Besides biochemical cues, accumulating evidence has …
fate needs to be well tailored. Besides biochemical cues, accumulating evidence has …
Mechanical regulation of mesenchymal stem cell differentiation
Biophysical cues play a key role in directing the lineage commitment of mesenchymal stem
cells or multipotent stromal cells (MSC s), but the mechanotransductive mechanisms at play …
cells or multipotent stromal cells (MSC s), but the mechanotransductive mechanisms at play …
The effects of dynamic loading on the intervertebral disc
Loading is important to maintain the balance of matrix turnover in the intervertebral disc
(IVD). Daily cyclic diurnal assists in the transport of large soluble factors across the IVD and …
(IVD). Daily cyclic diurnal assists in the transport of large soluble factors across the IVD and …
A 3D printed PCL/hydrogel construct with zone-specific biochemical composition mimicking that of the meniscus
Engineering the meniscus is challenging due to its bizonal structure; the tissue is
cartilaginous at the inner portion and fibrous at the outer portion. Here, we constructed an …
cartilaginous at the inner portion and fibrous at the outer portion. Here, we constructed an …
The role of mechanical signals in regulating chondrogenesis and osteogenesis of mesenchymal stem cells
It is becoming increasingly clear that mesenchymal stem cell (MSC) differentiation is
regulated by mechanical signals. Mechanical forces generated intrinsically within the cell in …
regulated by mechanical signals. Mechanical forces generated intrinsically within the cell in …
Influence of the mechanical environment on the regeneration of osteochondral defects
Articular cartilage is a highly specialised connective tissue of diarthrodial joints which
provides a smooth, lubricated surface for joint articulation and plays a crucial role in the …
provides a smooth, lubricated surface for joint articulation and plays a crucial role in the …
[PDF][PDF] A combination of shear and dynamic compression leads to mechanically induced chondrogenesis of human mesenchymal stem cells
There is great interest in how bone marrow derived stem cells make fate decisions.
Numerous studies have investigated the role of individual growth factors on mesenchymal …
Numerous studies have investigated the role of individual growth factors on mesenchymal …
[HTML][HTML] Long-term dynamic loading improves the mechanical properties of chondrogenic mesenchymal stem cell-laden hydrogels
Mesenchymal stem cells (MSCs) are an attractive cell source for cartilage tissue engineering
given their ability to undergo chondrogenesis in 3D culture systems. Mechanical forces play …
given their ability to undergo chondrogenesis in 3D culture systems. Mechanical forces play …
The response of bone marrow-derived mesenchymal stem cells to dynamic compression following TGF-β3 induced chondrogenic differentiation
The objective of this study was to investigate the hypothesis that the application of dynamic
compression following transforming growth factor-β3 (TGF-β3) induced differentiation will …
compression following transforming growth factor-β3 (TGF-β3) induced differentiation will …