Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

In eukaryotic cells, mitochondria are involved in a large array of metabolic and bioenergetic
processes that are vital for cell survival. Phospholipids are the main building blocks of …

Nonalcoholic fatty liver disease (NAFLD) is today considered the most common form of
chronic liver disease, affecting a high proportion of the population worldwide. NAFLD …

Cardiolipin is a unique phospholipid which is almost exclusively located in the inner
mitochondrial membrane where it is biosynthesized. Considerable progress has recently …

Redox-dependent processes influence most cellular functions, such as differentiation,
proliferation, and apoptosis. Mitochondria are at the center of these processes, as …

Mitochondria are the main organelles that produce adenosine 5′‐triphosphate (ATP) and
reactive oxygen species (ROS) in eukaryotic cells and meanwhile susceptible to oxidative …

Background: Targeting of drugs to the subcellular compartments represents one of the
modern trends in molecular pharmacology. The approach for targeting mitochondria was …

Astronauts returning from space shuttle missions or the International Space Station have
been diagnosed with various health problems such as bone demineralization, muscle …

Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease of the
motor system. It is characterized by the degeneration of both upper and lower motor …

Mitochondrial dysfunction plays a central role in myocardial ischemia-reperfusion (I/R)
injury. Increased reactive oxygen species production, impaired electron transport chain …