Despite efficient combination of the antiretroviral therapy (cART), which significantly
decreased mortality and morbidity of HIV-1 infection, a definitive HIV cure has not been …

People living with HIV are affected by the chronic consequences of neurocognitive
impairment (NCI) despite antiretroviral therapies that suppress viral replication, improve …

Viral encephalitis is still very prominent around the world, and traditional antiviral therapies
still have shortcomings. Some patients cannot get effective relief or suffer from serious …

Microglia are the resident macrophages of the central nervous system (CNS). They are a
heterogenous, exquisitely responsive, and highly plastic cell population, which enables …

HIV-associated neurocognitive disorders (HAND) affect over half of HIV-infected individuals,
despite antiretroviral therapy (ART). Therapeutically targetable mechanisms underlying …

Depression is a common neuropsychiatric disorder with long-term recurrent depressed
mood, pain and despair, pessimism and anxiety, and even suicidal tendencies as the main …

Discussion In the heterogenous spectrum of SARS-CoV-2–associated neurological
manifestations, 1 olfactory and gustative dysfunction has been proposed as an early and …

HIV-associated neurocognitive disorders (HAND) continue to affect a large proportion of
persons living with HIV despite effective viral suppression with combined antiretroviral …

HIV-associated neurocognitive disorders (HAND) are a leading cause of morbidity in up to
50% of individuals living with HIV, despite effective treatment with antiretroviral therapy …

As therapies are developed to cure HIV, it is important to protect the CNS from additional
immune-mediated damage. Adjunctive therapies to restore glial function, reduce …