Three-dimensional molecular structures can provide detailed information on biological
mechanisms and, for cases in which the molecular function affects human health, can …

Intrinsic antiviral immunity refers to a form of innate immunity that directly restricts viral
replication and assembly, thereby rendering a cell nonpermissive to a specific class or …

Retroviruses have long been a fertile model for discovering host–pathogen interactions and
their associated biological principles and processes. These advances have not only …

To replicate in their hosts, viruses have to navigate the complexities of the mammalian cell,
co-opting mechanisms of cellular physiology while defeating restriction factors that are …

The mechanism by which CD4 T cells are depleted in HIV-infected hosts remains poorly
understood. In ex vivo cultures of human tonsil tissue, CD4 T cells undergo a pronounced …

Human DNA cytosine-to-uracil deaminases catalyze mutations in both pathogen and
cellular genomes. APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H restrict human …

Retroviruses have evolved effective strategies to evade the host immune response, such as
high variability and latent infection. In addition, primate lentiviruses, such as HIV-1, have …

Human APOBEC3 enzymes are cellular DNA cytidine deaminases that inhibit and/or mutate
a variety of retroviruses, retrotransposons, and DNA viruses. Here, we report a detailed …

The ability to regulate and even target mutagenesis is an extremely valuable cellular asset.
Enzyme-catalyzed DNA cytosine deamination is a molecular strategy employed by …

Several members of the APOBEC3 family of cellular restriction factors provide intrinsic
immunity to the host against viral infection. Specifically, APOBEC3DE, APOBEC3F …