Biomolecular condensates are micron-scale compartments in eukaryotic cells that lack
surrounding membranes but function to concentrate proteins and nucleic acids. These …

The year 2017 marks the twentieth anniversary of terpenoid cyclase structural biology: a trio
of terpenoid cyclase structures reported together in 1997 were the first to set the foundation …

Biomolecular condensates concentrate macromolecules into discrete cellular foci without an
encapsulating membrane. Condensates are often presumed to increase enzymatic reaction …

Accelerated glycolysis is the main metabolic change observed in cancer, but the underlying
molecular mechanisms and their role in cancer progression remain poorly understood …

Cellular bodies such as P bodies and PML nuclear bodies (PML NBs) appear to be phase-
separated liquids organized by multivalent interactions among proteins and RNA molecules …

Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

Cells compartmentalize their intracellular environment to orchestrate countless
simultaneous biochemical processes. Many intracellular tasks rely on membrane-less …

Phase separation of biomolecules into condensates has emerged as a mechanism for
intracellular organization and affects many intracellular processes, including reaction …

Within each biological cell, surface-and volume-confined enzymes control a highly complex
network of chemical reactions. These reactions are efficient, timely, and spatially defined …

Metabolism has historically been studied at the levels of whole cells, whole tissues and
whole organisms. As a result, our understanding of how compartmentalization—the spatial …