Targeted alpha therapy: progress in radionuclide production, radiochemistry, and applications
This review outlines the accomplishments and potential developments of targeted alpha (α)
particle therapy (TAT). It discusses the therapeutic advantages of the short and highly …
particle therapy (TAT). It discusses the therapeutic advantages of the short and highly …
Radioimmunotherapy of human tumours
SM Larson, JA Carrasquillo, NKV Cheung… - Nature Reviews …, 2015 - nature.com
The eradication of cancer remains a vexing problem despite recent advances in our
understanding of the molecular basis of neoplasia. One therapeutic approach that has …
understanding of the molecular basis of neoplasia. One therapeutic approach that has …
Overview of the most promising radionuclides for targeted alpha therapy: The “hopeful eight”
Among all existing radionuclides, only a few are of interest for therapeutic applications and
more specifically for targeted alpha therapy (TAT). From this selection, actinium-225 …
more specifically for targeted alpha therapy (TAT). From this selection, actinium-225 …
ICRU REPORT 96, dosimetry-guided radiopharmaceutical therapy
The International Commission on Radiation Units and Measurements (ICRU), since its
inception in 1925, has had as its principal objective the development of internationally …
inception in 1925, has had as its principal objective the development of internationally …
α-emitters for radiotherapy: from basic radiochemistry to clinical studies—part 1
S Poty, LC Francesconi, MR McDevitt… - Journal of Nuclear …, 2018 - Soc Nuclear Med
With a short particle range and high linear energy transfer, α-emitting radionuclides
demonstrate high cell-killing efficiencies. Even with the existence of numerous radionuclides …
demonstrate high cell-killing efficiencies. Even with the existence of numerous radionuclides …
Molecular pathways: linking tumor microenvironment to epithelial–mesenchymal transition in metastasis
HY Jung, L Fattet, J Yang - Clinical Cancer Research, 2015 - AACR
During tumor development, tumor cells constantly communicate with the surrounding
microenvironment through both biochemical and biophysical cues. In particular, the tumor …
microenvironment through both biochemical and biophysical cues. In particular, the tumor …
Targeted alpha therapy, an emerging class of cancer agents: a review
Importance Targeted alpha therapy attempts to deliver systemic radiation selectively to
cancer cells while minimizing systemic toxic effects and may lead to additional treatment …
cancer cells while minimizing systemic toxic effects and may lead to additional treatment …
The elements of life and medicines
P Chellan, PJ Sadler - Philosophical Transactions of the …, 2015 - royalsocietypublishing.org
Which elements are essential for human life? Here we make an element-by-element journey
through the periodic table and attempt to assess whether elements are essential or not, and …
through the periodic table and attempt to assess whether elements are essential or not, and …
MIRD pamphlet no. 22 (abridged): radiobiology and dosimetry of α-particle emitters for targeted radionuclide therapy
The potential of α-particle emitters to treat cancer has been recognized since the early
1900s. Advances in the targeted delivery of radionuclides and radionuclide conjugation …
1900s. Advances in the targeted delivery of radionuclides and radionuclide conjugation …
Astatine-211 based radionuclide therapy: Current clinical trial landscape
P Albertsson, T Bäck, K Bergmark, A Hallqvist… - Frontiers in …, 2023 - frontiersin.org
Astatine-211 (211At) has physical properties that make it one of the top candidates for use
as a radiation source for alpha particle-based radionuclide therapy, also referred to as …
as a radiation source for alpha particle-based radionuclide therapy, also referred to as …