The notion of what qualifies as vascular dementia has varied greatly since the first mention
of dementia after apoplexy in ancient literature. Current insight points towards a …

This review summarizes the last decade of work by the ENIGMA (E nhancing N euro I
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …

Diffusion tensor imaging (DTI) is a well-established magnetic resonance imaging (MRI)
technique used for studying microstructural changes in the white matter. As with many other …

Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is
known about the phenotypic and genetic links of heart-brain systems. We quantified heart …

The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly
understood, and reported disease effects on the brain vary widely between studies. In an …

Alterations in white matter (WM) microstructure have been implicated in the pathophysiology
of major depressive disorder (MDD). However, previous findings have been inconsistent …

Subcortical structures, which include the basal ganglia and parts of the limbic system, have
key roles in learning, motor control and emotion, but also contribute to higher-order …

INTRODUCTION White matter in the human brain serves a critical role in organizing
distributed neural networks. Diffusion magnetic resonance imaging (dMRI) has enabled the …

Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the
pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies …

The epilepsies are commonly accompanied by widespread abnormalities in cerebral white
matter. ENIGMA-Epilepsy is a large quantitative brain imaging consortium, aggregating data …