[HTML][HTML] Histo-anatomical structure of the living isolated rat heart in two contraction states assessed by diffusion tensor MRI
Deformation and wall-thickening of ventricular myocardium are essential for cardiac pump
function. However, insight into the histo-anatomical basis for cardiac tissue re-arrangement …
function. However, insight into the histo-anatomical basis for cardiac tissue re-arrangement …
Recent progress in light sheet microscopy for biological applications
The introduction of light sheet fluorescence microscopy (LSFM) has overcome the
challenges in conventional optical microscopy. Among the recent breakthroughs in …
challenges in conventional optical microscopy. Among the recent breakthroughs in …
Robust anisotropic cellulose hydrogels fabricated via strong self-aggregation forces for cardiomyocytes unidirectional growth
The development of a facile and fast method to construct anisotropic hydrogels with the
ability to induce unidirectional growth of cells remains challenging. In this work, we …
ability to induce unidirectional growth of cells remains challenging. In this work, we …
The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats
ME Allen, ER Pennington, JB Perry, S Dadoo… - Communications …, 2020 - nature.com
Mitochondrial dysfunction contributes to cardiac pathologies. Barriers to new therapies
include an incomplete understanding of underlying molecular culprits and a lack of effective …
include an incomplete understanding of underlying molecular culprits and a lack of effective …
Stretch harmonizes sarcomere strain across the cardiomyocyte
BACKGROUND: Increasing cardiomyocyte contraction during myocardial stretch serves as
the basis for the Frank-Starling mechanism in the heart. However, it remains unclear how …
the basis for the Frank-Starling mechanism in the heart. However, it remains unclear how …
Cardiac thin filament regulation and the Frank–Starling mechanism
F Kobirumaki-Shimozawa, T Inoue, SA Shintani… - The journal of …, 2014 - Springer
The heart has an intrinsic ability to increase systolic force in response to a rise in ventricular
filling (the Frank–Starling law of the heart). It is widely accepted that the length dependence …
filling (the Frank–Starling law of the heart). It is widely accepted that the length dependence …
Silicon nanowire-induced maturation of cardiomyocytes derived from human induced pluripotent stem cells
The current inability to derive mature cardiomyocytes from human pluripotent stem cells has
been the limiting step for transitioning this powerful technology into clinical therapies. To …
been the limiting step for transitioning this powerful technology into clinical therapies. To …
Integrated analysis of contractile kinetics, force generation, and electrical activity in single human stem cell-derived cardiomyocytes
The quantitative analysis of cardiomyocyte function is essential for stem cell-based
approaches for the in vitro study of human cardiac physiology and pathophysiology. We …
approaches for the in vitro study of human cardiac physiology and pathophysiology. We …
SarcTrack: an adaptable software tool for efficient large-scale analysis of sarcomere function in hiPSC-cardiomyocytes
Rationale: Human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) in
combination with CRISPR/Cas9 genome editing provide unparalleled opportunities to study …
combination with CRISPR/Cas9 genome editing provide unparalleled opportunities to study …
Elastic serum-albumin based hydrogels: mechanism of formation and application in cardiac tissue engineering
Hydrogels are promising materials for mimicking the extra-cellular environment. Here, we
present a simple methodology for the formation of a free-standing viscoelastic hydrogel from …
present a simple methodology for the formation of a free-standing viscoelastic hydrogel from …