Transposable elements (TEs) comprise about half of the mammalian genome. TEs often
contain sequences capable of recruiting the host transcription machinery, which they use to …

Transposable elements (TEs) are a prolific source of tightly regulated, biochemically active
non-coding elements, such as transcription factor-binding sites and non-coding RNAs. Many …

Transposable elements are abundant in the human genome, and great strides have been
made in pinpointing variations in these repetitive sequences using whole-genome …

Transposable elements (TEs) are genetic elements with the ability to mobilize and replicate
themselves in a genome. Mammalian genomes are dominated by TEs, which can reach …

The life cycle of endogenous retroviruses (ERVs), also called long terminal repeat (LTR)
retrotransposons, begins with transcription by RNA polymerase II followed by reverse …

Since the discovery of transposons, their sheer abundance in host genomes has puzzled
many. While historically viewed as largely harmless 'parasitic'DNAs during evolution …

Chromatin loo** is important for gene regulation, and studies of 3D chromatin structure
across species and cell types have improved our understanding of the principles governing …

A major challenge in biology is determining how evolutionarily novel characters originate;
however, mechanistic explanations for the origin of new characters are almost completely …

Identification of noncoding drivers from thousands of somatic alterations in a typical tumor is
a difficult and unsolved problem. We report a computational framework, FunSeq2, to …

When the human genome project started, the major challenge was how to sequence a 3
billion letter code in an organized and cost-effective manner. When completed, the project …