The β-lactams retain a central place in the antibacterial armamentarium. In Gram-negative
bacteria, β-lactamase enzymes that hydrolyze the amide bond of the four-membered β …

With the advent of X-ray free-electron lasers (XFELs), new, high-throughput serial
crystallography techniques for macromolecular structure determination have emerged …

BACKGROUND Conformational changes are essential for the correct functioning of
biological macromolecules. Time-resolved x-ray crystallography extends an extremely …

Analyses of publicly available structural data reveal interesting insights into the impact of the
three‐dimensional (3D) structures of protein targets important for discovery of new drugs …

The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB),
funded by the United States National Science Foundation, National Institutes of Health, and …

The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of
delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of …

To advance microfluidic integration, we present the use of two-photon additive
manufacturing to fold 2D channel layouts into compact free-form 3D fluidic circuits with …

Abstract The European XFEL (EuXFEL) is a 3.4-km long X-ray source, which produces
femtosecond, ultrabrilliant and spatially coherent X-ray pulses at megahertz (MHz) repetition …

Biomolecular simulation is increasingly central to understanding and designing biological
molecules and their interactions. Detailed, physics‐based simulation methods are …

Highlights•Time-resolved serial femtosecond crystallography (tr-SFX) probes structure and
function in each sample.•X-ray free electron lasers (XFELS) provide atomic and electronic …