Rethinking schizophrenia
TR Insel - Nature, 2010 - nature.com
How will we view schizophrenia in 2030? Schizophrenia today is a chronic, frequently
disabling mental disorder that affects about one per cent of the world's population. After a …
disabling mental disorder that affects about one per cent of the world's population. After a …
Psychiatric comorbidities and schizophrenia
PF Buckley, BJ Miller, DS Lehrer… - Schizophrenia …, 2009 - academic.oup.com
Psychiatric comorbidities are common among patients with schizophrenia. Substance abuse
comorbidity predominates. Anxiety and depressive symptoms are also very common …
comorbidity predominates. Anxiety and depressive symptoms are also very common …
Predicting psychosis: meta-analysis of transition outcomes in individuals at high clinical risk
Context A substantial proportion of people at clinical high risk of psychosis will develop a
psychotic disorder over time. However, the risk of transition to psychosis varies between …
psychotic disorder over time. However, the risk of transition to psychosis varies between …
Schizophrenia,“just the facts” 4. Clinical features and conceptualization
R Tandon, HA Nasrallah, MS Keshavan - Schizophrenia research, 2009 - Elsevier
Although dementia praecox or schizophrenia has been considered a unique disease entity
for the past century, its definitions and boundaries have continued to vary over this period. At …
for the past century, its definitions and boundaries have continued to vary over this period. At …
Heterogeneity of psychosis risk within individuals at clinical high risk: a meta-analytical stratification
P Fusar-Poli, M Cappucciati, S Borgwardt… - JAMA …, 2016 - jamanetwork.com
Importance Individuals can be classified as being at clinical high risk (CHR) for psychosis if
they meet at least one of the ultra–high-risk (UHR) inclusion criteria (brief limited intermittent …
they meet at least one of the ultra–high-risk (UHR) inclusion criteria (brief limited intermittent …
Annual Research Review: Prevention of psychosis in adolescents–systematic review and meta‐analysis of advances in detection, prognosis and intervention
A Catalan, G Salazar de Pablo… - Journal of Child …, 2021 - Wiley Online Library
Background The clinical high‐risk state for psychosis (CHR‐P) paradigm has facilitated the
implementation of psychosis prevention into clinical practice; however, advancements in …
implementation of psychosis prevention into clinical practice; however, advancements in …
EPA guidance on the early intervention in clinical high risk states of psychoses
SJ Schmidt, F Schultze-Lutter… - European …, 2015 - cambridge.org
This guidance paper from the European Psychiatric Association (EPA) aims to provide
evidence-based recommendations on early intervention in clinical high risk (CHR) states of …
evidence-based recommendations on early intervention in clinical high risk (CHR) states of …
Early intervention in psychosis: concepts, evidence and future directions
The rise of the early intervention paradigm in psychotic disorders represents a maturing of
the therapeutic approach in psychiatry, as it embraces practical preventive strategies which …
the therapeutic approach in psychiatry, as it embraces practical preventive strategies which …
Stress and the hypothalamic pituitary adrenal axis in the developmental course of schizophrenia
Diathesis-stress models of schizophrenia and other psychotic disorders have dominated
theorizing about etiology for over three decades. More recently, with advances in our …
theorizing about etiology for over three decades. More recently, with advances in our …
Preliminary findings for two new measures of social and role functioning in the prodromal phase of schizophrenia
Introduction: Research on prediction and prevention of schizophrenia has increasingly
focused on prodromal (prepsychosis) social and role dysfunction as developmentally early …
focused on prodromal (prepsychosis) social and role dysfunction as developmentally early …