Therapeutic advances in COVID-19

N Murakami, R Hayden, T Hills, H Al-Samkari… - Nature Reviews …, 2023‏ - nature.com
Over 2 years have passed since the start of the COVID-19 pandemic, which has claimed
millions of lives. Unlike the early days of the pandemic, when management decisions were …

An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment

S Drożdżal, J Rosik, K Lechowicz, F Machaj… - Drug Resistance …, 2021‏ - Elsevier
The COVID-19 pandemic is one of the greatest threats to human health in the 21st century
with more than 257 million cases and over 5.17 million deaths reported worldwide (as of …

Repurposed antiviral drugs for COVID-19–interim WHO SOLIDARITY trial results

WHO Solidarity Trial Consortium, H Pan, R Peto… - MedRxiv, 2020‏ - medrxiv.org
ABSTRACT BACKGROUND WHO expert groups recommended mortality trials in
hospitalized COVID-19 of four re-purposed antiviral drugs. METHODS Study drugs were …

Repurposed antiviral drugs for Covid-19—interim WHO solidarity trial results

WHO Solidarity Trial Consortium - New England journal of …, 2021‏ - Mass Medical Soc
Abstract Background World Health Organization expert groups recommended mortality trials
of four repurposed antiviral drugs—remdesivir, hydroxychloroquine, lopinavir, and interferon …

Surviving sepsis campaign guidelines on the management of adults with coronavirus disease 2019 (COVID-19) in the ICU: first update

W Alhazzani, L Evans, F Alshamsi, MH Møller… - Critical care …, 2021‏ - journals.lww.com
BACKGROUND: The coronavirus disease 2019 pandemic continues to affect millions
worldwide. Given the rapidly growing evidence base, we implemented a living guideline …

SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1

X Sun, Y Liu, Z Huang, W Xu, W Hu, L Yi, Z Liu… - Cell Death & …, 2022‏ - nature.com
A recent mutation analysis suggested that Non-Structural Protein 6 (NSP6) of the Severe
Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a key determinant of the viral …

Reconciling estimates of global spread and infection fatality rates of COVID‐19: an overview of systematic evaluations

JPA Ioannidis - European journal of clinical investigation, 2021‏ - Wiley Online Library
Background Estimates of community spread and infection fatality rate (IFR) of COVID‐19
have varied across studies. Efforts to synthesize the evidence reach seemingly discrepant …

Global perspective of COVID‐19 epidemiology for a full‐cycle pandemic

JPA Ioannidis - European journal of clinical investigation, 2020‏ - Wiley Online Library
As of October 2020, there are> 1 million documented deaths with COVID‐19. Excess deaths
can be caused by both COVID‐19 and the measures taken. COVID‐19 shows extremely …

[HTML][HTML] RETRACTED: Deaths induced by compassionate use of hydroxychloroquine during the first COVID-19 wave: An estimate

A Pradelle, S Mainbourg, S Provencher, E Massy… - 2024‏ - Elsevier
Following publication, the Journal was made aware of readers' debate about this article. The
Journal received a number of Letters to the Editor and correspondence from readers. The …

Cost-effectiveness thresholds used by study authors, 1990-2021

PJ Neumann, DD Kim - Jama, 2023‏ - jamanetwork.com
The bars represent the distribution of ratings on a Likert scale (1= greatly favors preprint
abstract; 5= greatly favors published abstract) for the blinded comparison of the preprint and …