Transcription regulation networks control the expression of genes. The transcription
networks of well-studied microorganisms appear to be made up of a small set of recurring …

The discovery of microRNAs (miRNAs) has added a new player to the regulation of gene
expression. With the increasing number of molecular species involved in gene regulatory …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

The structural analysis of biological networks includes the ranking of the vertices based on
the connection structure of a network. To support this analysis we discuss centrality …

The signal-response characteristics of a living cell are determined by complex networks of
interacting genes, proteins, and metabolites. Understanding how cells respond to specific …

The existence of discrete phenotypic traits suggests that the complex regulatory processes
which produce them are functionally modular. These processes are usually represented by …

Technological advances in plant genetics integrated with systems biology and
bioinformatics has yielded a myriad of novel biological data and insights into plant …

Cells use feedback to implement a diverse range of regulatory functions. Building synthetic
feedback control systems may yield insight into the roles that feedback can play in regulation …

Background Inflammation triggered by infection or injury is tightly controlled by
glucocorticoid hormones which signal via a dedicated transcription factor, the Glucocorticoid …

Abstract microRNAs (miRNAs) function as genetic rheostats to control gene output. Based
on their role as modulators, it has been postulated that miRNAs canalize development and …