Sex differences are present across multiple non-reproductive organ cancers, with male
individuals generally experiencing higher incidence of cancer with poorer outcomes …

X inactivation represents a complex multi-layer epigenetic mechanism that profoundly
modifies chromatin composition and structure of one X chromosome in females. The …

Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …

Toll-like receptor 7 (TLR7) is critical to the induction of antiviral immunity, but TLR7 dosage
is also a key pathogenic factor in systemic lupus erythematosus (SLE), an autoimmune …

X chromosome inactivation (XCI) silences transcription from one of the two X chromosomes
in female mammalian cells to balance expression dosage between XX females and XY …

By analyzing the exomes of 12,332 unrelated Swedish individuals, including 4,877
individuals affected with schizophrenia, in ways informed by exome sequences from 45,376 …

There is a striking and unexplained male predominance across many cancer types. A subset
of X-chromosome genes can escape X-inactivation, which would protect females from …

Somatic cells of human males and females have 45 chromosomes in common, including
the" active" X chromosome. In males the 46 th chromosome is a Y; in females it is an" …

X chromosome inactivation (XCI) silences most genes on one X chromosome in female
mammals, but some genes escape XCI. To identify escape genes in vivo and to explore …

X-chromosome inactivation (XCI) achieves dosage compensation between males and
females through the silencing of the majority of genes on one of the female X chromosomes …