Computational enzymology is a rapidly maturing field that is increasingly integral to
understanding mechanisms of enzyme-catalyzed reactions and their practical applications …

In an effort to discover small molecule drug candidates with attractive toxicity profiles, the
pharmaceutical industry has predominantly sought compounds that modulate target proteins …

Fatty acid amide hydrolase (FAAH) is an important enzyme creditworthy of hydrolyzing
endocannabinoids and related-amidated signalling lipids, discovery of which has pioneered …

Identifying points of control in inflammation is essential to discovering safe and effective
antiinflammatory medicines. Palmitoylethanolamide (PEA) is a naturally occurring lipid …

Background: Fatty acid amide hydrolase (FAAH) is an integral membrane enzyme that
hydrolyzes the endocannabinoid anandamide and related amidated signaling lipids …

The medicinal use of cannabis dates back to early recorded history. As early as 2600 BC,
ancient Chinese texts record the use of cannabis for the relief of numerous conditions …

The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH) -
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The modulation of the endocannabinoid system is emerging as a viable avenue for the
treatment of neurodegeneration, being involved in neuroprotective and anti-inflammatory …

The endocannabinoid system regulates a wide range of physiological processes including
pain, inflammation, and cognitive/emotional states. URB597 is one of the best characterized …

It has been shown for a wide range of epoxy compounds that their interaction with
triphenylphosphonium triflate occurs with a high chemoselectivity and leads to the formation …