The human brain consumes 20% of the total basal oxygen (O 2) budget to support ATP
intensive neuronal activity. Without sufficient O 2 to support ATP demands, neuronal activity …

Peroxiredoxins (Prxs) are a ubiquitous family of cysteine-dependent peroxidase enzymes
that play dominant roles in regulating peroxide levels within cells. These enzymes, often …

Significance: The detrimental effects of ionizing radiation (IR) involve a highly orchestrated
series of events that are amplified by endogenous signaling and culminating in oxidative …

The cysteine (Cys) proteome is a major component of the adaptive interface between the
genome and the exposome. The thiol moiety of Cys undergoes a range of biologic …

Hydrogen peroxide is generated in numerous biological processes and is implicated as the
main transmitter of redox signals. Although a strong oxidant, high activation energy barriers …

Significance: Disulfides are important building blocks in the secondary and tertiary structures
of proteins, serving as inter-and intra-subunit cross links. Disulfides are also the major …

Peroxiredoxins (Prxs) constitute a major family of peroxidases, with mammalian cells
expressing six Prx isoforms (PrxI to PrxVI). Cells produce hydrogen peroxide (H2O2) at …

During the cellular oxidation of fuels, electrons are used to power the proton pumps of the
mitochondrial electron transport chain (ETC) and ultimately drive ATP synthesis and the …

Irreversible oxidation of Cys residues to sulfinic/sulfonic forms typically impairs protein
function. We found that persulfidation (CysSSH) protects Cys from irreversible oxidative loss …

Abstract Significance: Hydrogen peroxide (H 2 O 2) is generated in numerous biological
processes. It transmits cellular signals, contributes to oxidative folding of exported proteins …