Compressive stresses in cancer: characterization and implications for tumour progression and treatment
JA Linke, LL Munn, RK Jain - Nature Reviews Cancer, 2024 - nature.com
Beyond their many well-established biological aberrations, solid tumours create an
abnormal physical microenvironment that fuels cancer progression and confers treatment …
abnormal physical microenvironment that fuels cancer progression and confers treatment …
Tumor-associated macrophages: Prognostic and therapeutic targets for cancer in humans and dogs
RV Brady, DH Thamm - Frontiers in Immunology, 2023 - frontiersin.org
Macrophages are ancient, phagocytic immune cells thought to have their origins 500 million
years ago in metazoan phylogeny. The understanding of macrophages has evolved to …
years ago in metazoan phylogeny. The understanding of macrophages has evolved to …
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models
Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma trials. Here, we
found that ICBs induce cerebral edema in some patients and mice with glioblastoma …
found that ICBs induce cerebral edema in some patients and mice with glioblastoma …
[HTML][HTML] Mannan-Decorated Lipid Calcium Phosphate Nanoparticle Vaccine Increased the Antitumor Immune Response by Modulating the Tumor Microenvironment
L Wu, L Yang, X Qian, W Hu, S Wang… - Journal of Functional …, 2024 - mdpi.com
With the rapid development of tumor immunotherapy, nanoparticle vaccines have attracted
much attention as potential therapeutic strategies. A systematic review and analysis must be …
much attention as potential therapeutic strategies. A systematic review and analysis must be …
Strategies to overcome myeloid cell induced immune suppression in the tumor microenvironment
Cancer progression and metastasis due to tumor immune evasion and drug resistance is
strongly associated with immune suppressive cellular responses, particularly in the case of …
strongly associated with immune suppressive cellular responses, particularly in the case of …
Cancer immunotherapy
7 Nuclear Transport Inhibitors Page 1 7 Nuclear Transport Inhibitors CHERYL LONDON* Tufts
University, North Grafton, Massachusetts, USA Introduction: Regulation of Nuclear Transport The …
University, North Grafton, Massachusetts, USA Introduction: Regulation of Nuclear Transport The …
Companion animals as a key to success for translating radiation therapy research into the clinic
IF Vanhaezebrouck, ML Scarpelli - Cancers, 2023 - mdpi.com
Simple Summary Companion animals with cancer have participated in veterinary radiation
oncology research. This research has led to greater understanding of radiation safety and …
oncology research. This research has led to greater understanding of radiation safety and …
Direct comparison of canine and human immune responses using transcriptomic and functional analyses
The canine spontaneous cancer model is increasingly utilized to evaluate new combined
cancer immunotherapy approaches. While the major leukocyte subsets and phenotypes are …
cancer immunotherapy approaches. While the major leukocyte subsets and phenotypes are …
Bringing the Genomic Revolution to Comparative Oncology: Human and Dog Cancers
Dogs are humanity's oldest friend, the first species we domesticated 20,000–40,000 years
ago. In this unequaled collaboration, dogs have inadvertently but serendipitously been …
ago. In this unequaled collaboration, dogs have inadvertently but serendipitously been …
Chronic adrenergic stress and generation of myeloid‐derived suppressor cells: Implications for cancer immunotherapy in dogs
Recent studies have highlighted a key role played by the sympathetic nervous system (SNS)
and adrenergic stress in mediating immune suppression associated with chronic …
and adrenergic stress in mediating immune suppression associated with chronic …