Neurological disorders significantly outnumber diseases in other therapeutic areas.
However, develo** drugs for central nervous system (CNS) disorders remains the most …

CNS disorders are indications with a very high unmet medical needs, relatively smaller
number of available drugs, and a subpar satisfaction level among patients and caregiver …

Vitrification is an alternative to cryopreservation by freezing that enables hydrated living cells
to be cooled to cryogenic temperatures in the absence of ice. Vitrification simplifies and …

Quantitative structure–activity relationship modeling using machine learning techniques
constitutes a complex computational problem, where the identification of the most …

A successful passage of the blood–brain barrier (BBB) is an essential prerequisite for the
drug molecules designed to act on the central nervous system. The logarithm of blood–brain …

Necessitated by the subzero temperatures and seasonal exposure to ice, various organisms
have developed a remarkably effective means to survive the harsh climate of their natural …

The hERG potassium channel serves as an annexed target for drug discovery because the
associated off-target inhibitory activity may cause serious cardiotoxicity. Quantitative …

Controlling the formation and growth of ice is essential to successfully cryopreserve cells,
tissues and biologics. Current efforts to identify materials capable of modulating ice growth …

Viral infectivity factor (Vif) is protective against APOBEC3G (A3G)-mediated viral cDNA
hypermutations, and development of molecules that inhibit Vif mediated A3G degradation is …

Discovery of new inorganic solid materials can be accelerated with the aid of a reliable
computational tool for predicting the associated electrochemical properties. Hence, we …