The emerging hallmarks of cancer metabolism
Tumorigenesis is dependent on the reprogramming of cellular metabolism as both direct
and indirect consequence of oncogenic mutations. A common feature of cancer cell …
and indirect consequence of oncogenic mutations. A common feature of cancer cell …
Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study
YL Wu, ZJ Lin, CC Li, X Lin, SK Shan, B Guo… - … and Targeted Therapy, 2023 - nature.com
Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …
Metabolic regulation of gene expression through histone acylations
Eight types of short-chain Lys acylations have recently been identified on histones:
propionylation, butyrylation, 2-hydroxyisobutyrylation, succinylation, malonylation …
propionylation, butyrylation, 2-hydroxyisobutyrylation, succinylation, malonylation …
The growing landscape of lysine acetylation links metabolism and cell signalling
Lysine acetylation is a conserved protein post-translational modification that links acetyl-
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …
Histone modifications and cancer
JE Audia, RM Campbell - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
Histone posttranslational modifications represent a versatile set of epigenetic marks
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …
Lateral thinking: how histone modifications regulate gene expression
M Lawrence, S Daujat, R Schneider - Trends in Genetics, 2016 - cell.com
The DNA of each cell is wrapped around histone octamers, forming so-called 'nucleosomal
core particles'. These histone proteins have tails that project from the nucleosome and many …
core particles'. These histone proteins have tails that project from the nucleosome and many …
[HTML][HTML] The world of protein acetylation
Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
[HTML][HTML] Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification
We report the identification of 67 previously undescribed histone modifications, increasing
the current number of known histone marks by about 70%. We further investigated one of the …
the current number of known histone marks by about 70%. We further investigated one of the …
Functions of bromodomain-containing proteins and their roles in homeostasis and cancer
T Fujisawa, P Filippakopoulos - Nature reviews Molecular cell biology, 2017 - nature.com
Bromodomains (BRDs) are evolutionarily conserved protein–protein interaction modules
that are found in a wide range of proteins with diverse catalytic and scaffolding functions and …
that are found in a wide range of proteins with diverse catalytic and scaffolding functions and …
SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways
Protein function is regulated by diverse posttranslational modifications. The mitochondrial
sirtuin SIRT5 removes malonyl and succinyl moieties from target lysines. The spectrum of …
sirtuin SIRT5 removes malonyl and succinyl moieties from target lysines. The spectrum of …