Interleukin-6 (IL-6) is a pleiotropic cytokine involved in immune regulation. It can activate
janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) signaling …

Abstract The Janus kinases (JAKs) and signal transducer and activator of transcription
(STAT) proteins, particularly STAT3, are among the most promising new targets for cancer …

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, yet it
remains refractory to systemic therapy. Elimination of senescent cells has emerged as a …

Although obesity is known to be critical for cancer development, how obesity negatively
impacts antitumor immune responses remains largely unknown. Here, we show that …

Many cancers feature cellular hierarchies that are driven by tumor-initiating cancer stem
cells (CSC) and rely on complex interactions with the tumor microenvironment. Standard cell …

Cancer cells display phenotypic equilibrium between the stem-like and differentiated states
during neoplastic homeostasis. The functional and mechanistic implications of this …

Glioblastomas (GBM) are the most common primary brain tumor with a median survival of 15
months. A population of cells with stem cell properties (glioblastoma stem cells, GSCs) …

Glioblastoma is the most malignant tumor occurring in the human central nervous system
with overall median survival time< 14.6 months. Current treatments such as chemotherapy …

In-depth knowledge of cancer molecular and cellular mechanisms have revealed a strong
regulation of cancer development and progression by the inflammation which orchestrates …

Tissues with defined cellular hierarchies in development and homeostasis give rise to
tumors with cellular hierarchies, suggesting that tumors recapitulate specific tissues and …