Mendelian randomization: concepts and scope
RC Richmond, GD Smith - Cold Spring …, 2022 - perspectivesinmedicine.cshlp.org
Mendelian randomization (MR) is a method of studying the causal effects of modifiable
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease
Abstract Growth differentiation factor 15 (GDF15) is a member of the TGFβ superfamily
whose expression is increased in response to cellular stress and disease as well as by …
whose expression is increased in response to cellular stress and disease as well as by …
Plasma proteomic associations with genetics and health in the UK Biobank
Abstract The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium
characterizing the plasma proteomic profiles of 54,219 UK Biobank participants. Here we …
characterizing the plasma proteomic profiles of 54,219 UK Biobank participants. Here we …
Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets
Circulating proteins have important functions in inflammation and a broad range of diseases.
To identify genetic influences on inflammation-related proteins, we conducted a genome …
To identify genetic influences on inflammation-related proteins, we conducted a genome …
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
We assembled an ancestrally diverse collection of genome-wide association studies
(GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls …
(GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls …
Persistent complement dysregulation with signs of thromboinflammation in active Long Covid
Long Covid is a debilitating condition of unknown etiology. We performed multimodal
proteomics analyses of blood serum from COVID-19 patients followed up to 12 months after …
proteomics analyses of blood serum from COVID-19 patients followed up to 12 months after …
Large-scale integration of the plasma proteome with genetics and disease
The plasma proteome can help bridge the gap between the genome and diseases. Here we
describe genome-wide association studies (GWASs) of plasma protein levels measured with …
describe genome-wide association studies (GWASs) of plasma protein levels measured with …
Stroke genetics informs drug discovery and risk prediction across ancestries
Previous genome-wide association studies (GWASs) of stroke—the second leading cause of
death worldwide—were conducted predominantly in populations of European ancestry …
death worldwide—were conducted predominantly in populations of European ancestry …
Large-scale plasma proteomics comparisons through genetics and disease associations
High-throughput proteomics platforms measuring thousands of proteins in plasma combined
with genomic and phenotypic information have the power to bridge the gap between the …
with genomic and phenotypic information have the power to bridge the gap between the …
The sequences of 150,119 genomes in the UK Biobank
Detailed knowledge of how diversity in the sequence of the human genome affects
phenotypic diversity depends on a comprehensive and reliable characterization of both …
phenotypic diversity depends on a comprehensive and reliable characterization of both …