General principles of protein structure, stability, and folding kinetics have recently been
explored in computer simulations of simple exact lattice models. These models represent …

Publisher Summary This chapter summarizes the experimental information on protein
energetics. This field is develo** fast and the concept of the energetics of protein structure …

Molecular dynamics (MD) simulations have become increasingly popular in studying the
motions and functions of biomolecules. The accuracy of the simulation, however, is highly …

All published rotamer libraries contain some rotamers that exhibit impossible internal atomic
overlaps if built in ideal geometry with all hydrogen atoms. Removal of uncertain residues …

Thermodynamic studies have demonstrated the central importance of a large negative heat
capacity change (Δ C° assoc) in site-specific protein-DNA recognition. Dissection of the …

In order to identify strong transmembrane helix packing motifs, we have selected
transmembrane domains exhibiting high-affinity homo-oligomerization from a randomized …

For 35 years, the prevailing view has been that the hydrophobic effect is the dominant force
in protein folding. The importance of hydrogen bonding was always clear, but whether it …

The understanding of molecular recognition processes of small ligands and biological
macromolecules requires a complete characterization of the binding energetics and …

Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …

Helix propensities of the amino acids have been measured in alanine‐based peptides in the
absence of helix‐stabilizing side‐chain interactions. Fifty‐eight peptides have been studied …